Branched-chain amino acids in disease.
作者信息
White Phillip J, Newgard Christopher B
机构信息
Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA, and Department of Pharmacology and Cancer Biology, and Department of Medicine, Endocrine Division, Duke University Medical Center, Durham, NC 27701, USA.
出版信息
Science. 2019 Feb 8;363(6427):582-583. doi: 10.1126/science.aav0558.
Abstract
摘要
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.BCKDH 激酶和磷酸酶通过调节 ATP-柠檬酸裂解酶整合支链氨基酸和脂质代谢。
Cell Metab. 2018 Jun 5;27(6):1281-1293.e7. doi: 10.1016/j.cmet.2018.04.015. Epub 2018 May 17.
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Fructose metabolism and metabolic disease.果糖代谢与代谢性疾病。
J Clin Invest. 2018 Feb 1;128(2):545-555. doi: 10.1172/JCI96702.
4
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Diabetes Care. 2017 Dec;40(12):1779-1786. doi: 10.2337/dc17-1642. Epub 2017 Oct 18.
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Cell Metab. 2017 Jan 10;25(1):43-56. doi: 10.1016/j.cmet.2016.09.018. Epub 2016 Oct 27.
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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.支链氨基酸代谢受损的遗传易感性与2型糖尿病风险：一项孟德尔随机化分析
PLoS Med. 2016 Nov 29;13(11):e1002179. doi: 10.1371/journal.pmed.1002179. eCollection 2016 Nov.
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Mol Metab. 2016 Apr 22;5(7):538-551. doi: 10.1016/j.molmet.2016.04.006. eCollection 2016 Jul.
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Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.支链氨基酸的分解代谢缺陷促进心力衰竭。
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