Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra, 411038, India.
Department of Pharmacology, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, 411041, India.
Naunyn Schmiedebergs Arch Pharmacol. 2019 Jun;392(6):659-668. doi: 10.1007/s00210-019-01623-4. Epub 2019 Feb 8.
Ferulic acid (FA) is a phenolic compound with potent antioxidant activity. The objective of the study was to study the protective effects of FA on doxorubicin (Dox)-induced myocardial toxicity in rats. Wistar rats received vehicle (control) or Dox (20 mg/kg, i.p.) or telmisartan (Tel; 10 mg/kg, p.o.) or ferulic acid (20 mg/kg and 40 mg/kg, p.o.) for 7 days followed by treatment with Dox (20) on the fifth day of treatment, except the control group. On day 8, electrocardiographic parameters were recorded followed by blood withdrawal and then the animals were sacrificed for histopathology. Administration of Dox showed prolonged RR, QTc interval, and QRS complex. The levels of serum CK-MB, LDH, IL-1β, and IL-6 were significantly increased (p < 0.01). Similarly, levels of Ca, Mg ATPase, and Ca ATPase and expression of ANP and BNP were significantly higher as compared to the control. In the FA-treated group, ECG was normal. The serum levels of CK-MB, LDH, IL-1β, and IL-6 were not elevated. Heart tissue Ca, Mg ATPase, and Ca ATPase did not show a statistical difference compared to the control group. The FA treatment attenuated the expression of ANP and BNP. FA (20 and 40) augmented myocardial GSH and Na/K ATPase. Histopathology of the heart confirmed the cardioprotective effect of FA.
阿魏酸（FA）是一种具有强大抗氧化活性的酚类化合物。本研究旨在研究 FA 对阿霉素（Dox）诱导的大鼠心肌毒性的保护作用。Wistar 大鼠给予载体（对照）或 Dox（20mg/kg，腹腔注射）或替米沙坦（Tel；10mg/kg，口服）或阿魏酸（20mg/kg 和 40mg/kg，口服）7 天，然后在治疗的第 5 天给予 Dox（20），除对照组外。第 8 天，记录心电图参数，然后采血，然后处死动物进行组织病理学检查。Dox 给药显示 RR、QTc 间隔和 QRS 复合体延长。血清 CK-MB、LDH、IL-1β 和 IL-6 水平显著升高（p<0.01）。同样，与对照组相比，Ca、Mg-ATP 酶和 Ca-ATP 酶的水平以及 ANP 和 BNP 的表达显著升高。在 FA 治疗组，心电图正常。血清 CK-MB、LDH、IL-1β 和 IL-6 水平未升高。与对照组相比，心脏组织 Ca、Mg-ATP 酶和 Ca-ATP 酶没有统计学差异。FA 治疗减轻了 ANP 和 BNP 的表达。FA（20 和 40）增加了心肌 GSH 和 Na/K-ATP 酶。心脏组织病理学证实了 FA 的心脏保护作用。
