Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Neurology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Life Sci. 2019 Mar 15;221:99-108. doi: 10.1016/j.lfs.2019.01.052. Epub 2019 Feb 5.
Peripheral nerve injury (PNI) is a common life-changing disability of peripheral nervous system with significant socioeconomic consequences. Conventional therapeutic approaches for PNI have several drawbacks such as need to autologous nerve scarifying, surplus surgery, and difficult accessibility to donor nerve; therefore, other therapeutic strategies such as mesenchymal stem cells (MSCs) therapy are getting more interesting. MSCs have been proved to be safe and efficient in numerous degenerative diseases of central and peripheral nervous systems. In this paper, we review novel biotechnological advancements in treating PNI using MSCs.
周围神经损伤（PNI）是一种常见的外周神经系统改变生活的残疾，具有重大的社会经济后果。PNI 的传统治疗方法有几个缺点，例如需要自体神经损伤、多余的手术和供体神经难以接近；因此，其他治疗策略，如间充质干细胞（MSCs）治疗，越来越受到关注。MSCs 已被证明在中枢和周围神经系统的许多退行性疾病中是安全有效的。在本文中，我们综述了使用 MSCs 治疗 PNI 的新生物技术进展。
