用于药物的电化学发光生物传感方法的最新进展。
Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals.
作者信息
Zhang Yu, Zhang Rui, Yang Xiaolin, Qi Honglan, Zhang Chengxiao
机构信息
Medpace Bioanalytical Laboratories, 5365 Medpace Way, Cincinnati, OH 45227, USA.
School of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN 47405, USA.
出版信息
J Pharm Anal. 2019 Feb;9(1):9-19. doi: 10.1016/j.jpha.2018.11.004. Epub 2018 Nov 22.
Abstract
Electrogenerated chemiluminescence (electrochemiluminescence, ECL) generates species at electrode surfaces, which undergoes electron-transfer reactions and forms excited states to emit light. It has become a very powerful analytical technique and has been widely used in such as clinical testing, biowarfare agent detection, and pharmaceutical analysis. This review focuses on the current trends of molecular recognition-based biosensing methods for pharmaceutical analysis since 2010. It introduces a background of ECL and presents the recent ECL developments in ECL immunoassay (ECLIA), immunosensors, enzyme-based biosensors, aptamer-based biosensors, and molecularly imprinted polymers (MIP)-based sensors. At last, the future perspective for these analytical methods is briefly discussed.
摘要
电致化学发光（电化学发光，ECL）在电极表面产生物质，该物质发生电子转移反应并形成激发态以发光。它已成为一种非常强大的分析技术，并已广泛应用于临床检测、生物战剂检测和药物分析等领域。本综述聚焦于自2010年以来基于分子识别的药物分析生物传感方法的当前趋势。介绍了ECL的背景，并阐述了ECL免疫分析（ECLIA）、免疫传感器、酶基生物传感器、适体基生物传感器和分子印迹聚合物（MIP）基传感器中ECL的最新进展。最后，简要讨论了这些分析方法的未来前景。
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