Department of Pediatrics, Children's Hospital V. Buzzi, University of Milan, Milan 20154, Italy.
Faculty of Social Sciences, University of Bradford, Bradford BD7 1DP, UK.
Nutrients. 2019 Feb 9;11(2):359. doi: 10.3390/nu11020359.
The prevalence of food allergy appears to be steadily increasing in infants and young children. One of the major challenges of modern clinical nutrition is the implementation of individualized nutritional recommendations. The management of food allergy (FA) has seen major changes in recent years. While strict allergen avoidance is still the key treatment principle, it is increasingly clear that the avoidance diet should be tailored according to the patient FA phenotype. Furthermore, new insights into the gut microbiome and immune system explain the rising interest in tolerance induction and immunomodulation by microbiota-targeted dietary intervention. This review article focuses on the nutritional management of IgE mediated food allergy, mainly focusing on different aspects of the avoidance diet. A personalized approach to managing the food allergic individual is becoming more feasible as we are learning more about diagnostic modalities and allergic phenotypes. However, some unmet needs should be addressed to fully attain this goal.
食物过敏的患病率似乎在婴儿和幼儿中稳步上升。现代临床营养面临的主要挑战之一是实施个性化营养建议。近年来,食物过敏(FA)的管理发生了重大变化。虽然严格避免过敏原仍然是关键的治疗原则,但越来越明显的是,回避饮食应根据患者的 FA 表型进行调整。此外,对肠道微生物组和免疫系统的新认识解释了人们对通过针对微生物组的饮食干预诱导耐受和免疫调节的兴趣日益增加。本文重点介绍 IgE 介导的食物过敏的营养管理,主要关注回避饮食的不同方面。随着我们对诊断方式和过敏表型的了解越来越多,管理食物过敏个体的个性化方法变得越来越可行。然而,为了充分实现这一目标,仍需要解决一些未满足的需求。