窄谱中波紫外线（NB - UVB）治疗越南慢性苔藓样糠疹（PLC）的疗效
The Effectiveness of Narrow Band Uvb (Nb-Uvb) In the Treatment of Pityriasis Lichenoides Chronica (PLC) In Vietnam.
作者信息
Huu Doanh Le, Minh Thao Ngo, Van Thuong Nguyen, Minh Phuong Pham Thi, Huu Nghi Dinh, Cam Van Tran, Huyen My Le, Nguyet Minh Vu, Thi Mai Le, Thu Hien Do Thi, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
机构信息
National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Hanoi Medical University, Vietnam.
出版信息
Open Access Maced J Med Sci. 2019 Jan 25;7(2):221-223. doi: 10.3889/oamjms.2019.055. eCollection 2019 Jan 30.
AIM
This prospective clinical study presents the experiences with NB-UVB monotherapy in the treatment of PLC on Vietnamese patients.
METHODS
We enrolled at National Hospital of Dermatology and Venereology (NHDV), Vietnam, 29 PLC patients with generalised disease involving at least 60% of the total body surface (based on Nine's Rule) and/or failed to respond to other modalities of treatment. Patients were treated with NB-UVB followed the guideline of the psoriatic treatment of AAD-2010, three times weekly.
RESULTS
A complete response (CR) was seen in 24 out of 29 PLC patients (82.8%) with a mean cumulative dose of 9760.5 mJ/cm after a mean treatment period of 4.6 weeks (13.8 ± 7.4 exposures). Mild side effects were observed: 69% erythema minimum, 55.2% irritation related to dry skin. No severe side effects were seen during the study. No relapses occurred in 24 CR patients within a mean period of 3 months after the last treatment.
CONCLUSION
NB-UVB therapy is an effective and safe option for the treatment and management of PLC.
目的
本前瞻性临床研究介绍了窄谱中波紫外线（NB-UVB）单一疗法治疗越南患者蕈样肉芽肿（PLC）的经验。
方法
我们在越南皮肤病与性病国家医院（NHDV）招募了29例PLC患者，这些患者患有全身性疾病，累及至少60%的体表面积（基于九分法）和/或对其他治疗方式无反应。患者按照美国皮肤病学会（AAD）2010年银屑病治疗指南接受NB-UVB治疗，每周三次。
结果
29例PLC患者中有24例（82.8%）出现完全缓解（CR），平均治疗期4.6周（13.8±7.4次照射）后平均累积剂量为9760.5 mJ/cm²。观察到轻微副作用：69%出现最小红斑，55.2%出现与皮肤干燥相关的刺激。研究期间未观察到严重副作用。24例CR患者在最后一次治疗后的平均3个月内未复发。
结论
NB-UVB疗法是治疗和管理PLC的有效且安全的选择。
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