越南人群瘢痕疙瘩病灶内注射博来霉素的成功治疗
Successful Treatment of Intralesional Bleomycin in Keloids of Vietnamese Population.
作者信息
Huu Nghi Dinh, Huu Sau Nguyen, Thi Xuan Le, Van Thuong Nguyen, Minh Phuong Pham Thi, Minh Trang Trinh, Van Tam Hoang, Cam Van Tran, Huyen My Le, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello
机构信息
National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
Unit of Dermatology, University of Parma, Parma, Italy.
出版信息
Open Access Maced J Med Sci. 2019 Jan 29;7(2):298-299. doi: 10.3889/oamjms.2019.099. eCollection 2019 Jan 30.
BACKGROUND
Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of keloids.
AIM
To evaluate the efficacy of bleomycin injected in the injury for keloids treatment.
METHODS
The treatment was carried out in 55 patients having 120 keloids of different sizes and locations. Average treatments were 4 times.
RESULTS
Complete flattening was 70.8%, highly significant flattening was 8.3%, no patient of minimal flattening. Systemic side-effects of bleomycin were not evaluated, but local side-effects were mainly pains (100%), blisters (78.3%), ulceration (5.8%), and hyperpigmentation (56.7%).
CONCLUSION
The percentage of patients recurring 6, 12, 15, 18 months after the last treatment were 3.8, 15.4, 45.5, 50%, respectively.
背景
瘢痕疙瘩是皮肤组织对早期损伤的一种过度反应状态，其特征为成纤维细胞增殖以及损伤部位胶原蛋白过度生成。由于治疗反应率低且治疗后复发风险高，瘢痕疙瘩的治疗是一项巨大挑战。我们发现博来霉素在瘢痕疙瘩治疗中具有前景。
目的
评估向损伤部位注射博来霉素治疗瘢痕疙瘩的疗效。
方法
对55例患者共120个大小和部位各异的瘢痕疙瘩进行治疗。平均治疗次数为4次。
结果
完全扁平率为70.8%，高度显著扁平率为8.3%，无最小扁平的患者。未评估博来霉素的全身副作用，但局部副作用主要为疼痛（100%）、水疱（78.3%）、溃疡（5.8%）和色素沉着（56.7%）。
结论
最后一次治疗后6、12、15、18个月复发的患者百分比分别为3.8%、15.4%、45.5%、50%。
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