• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

依库珠单抗成功治疗一例伴发的溶血性尿毒症综合征。

Successful treatment of a associated haemolytic uraemic syndrome by eculizumab.

作者信息

Jeantet Guillaume, Pernin Vincent, Brunot Vincent, Roccabianca Arnaud, Macombe Anouk, Szwarc Ilan, Klouche Kada, Loirat Chantal, Mourad Georges, Frémeaux-Bacchi Véronique, Le Quintrec Moglie

机构信息

Department of Nephrology and Kidney Transplantation, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.

Critical Care Department, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.

出版信息

Clin Kidney J. 2019 Feb;12(1):106-109. doi: 10.1093/ckj/sfy019. Epub 2018 Mar 20.

DOI:10.1093/ckj/sfy019
PMID:30746136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6366139/
Abstract

Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchanges, eculizumab (anti-C5 antibody) resulted in a favourable outcome.

摘要

溶血性尿毒症综合征（HUS）是由[具体病原体]引起的侵袭性感染的一种罕见并发症（特别是在成人中），尤其是由[具体病原体]引起的（典型溶血尿毒综合征，SP-HUS）。在此，我们报告一例不寻常的病例，一名53岁男性出现伴有严重多脏器受累的SP-HUS。在支持治疗和血浆置换失败后，依库珠单抗（抗C5抗体）带来了良好的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf0/6366139/964c95171654/sfy019f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf0/6366139/697f9623e277/sfy019f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf0/6366139/964c95171654/sfy019f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf0/6366139/697f9623e277/sfy019f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf0/6366139/964c95171654/sfy019f2.jpg

相似文献

1
Successful treatment of a associated haemolytic uraemic syndrome by eculizumab.依库珠单抗成功治疗一例伴发的溶血性尿毒症综合征。
Clin Kidney J. 2019 Feb;12(1):106-109. doi: 10.1093/ckj/sfy019. Epub 2018 Mar 20.
2
Novel aspects of atypical haemolytic uraemic syndrome and the role of eculizumab.非典型溶血尿毒综合征的新特征及依库珠单抗的作用
Nephrol Dial Transplant. 2014 Sep;29 Suppl 4:iv131-41. doi: 10.1093/ndt/gfu235.
3
The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome.补体在肺炎链球菌相关性溶血尿毒综合征中的作用。
Nephrol Dial Transplant. 2013 Sep;28(9):2237-45. doi: 10.1093/ndt/gft198. Epub 2013 Jun 19.
4
Eculizumab and drug-induced haemolytic-uraemic syndrome.依库珠单抗与药物性溶血尿毒综合征。
Clin Kidney J. 2013 Oct;6(5):484-5. doi: 10.1093/ckj/sft078. Epub 2013 Sep 5.
5
Prevention and treatment of atypical haemolytic uremic syndrome after kidney transplantation.肾移植后非典型溶血尿毒综合征的防治
Nephrology (Carlton). 2016 Jul;21 Suppl 1:9-13. doi: 10.1111/nep.12776.
6
Eculizumab in the treatment of Shiga toxin haemolytic uraemic syndrome.依库珠单抗治疗志贺毒素溶血尿毒综合征。
Pediatr Nephrol. 2019 Sep;34(9):1485-1492. doi: 10.1007/s00467-018-4025-0. Epub 2018 Jul 30.
7
Ocular involvement in atypical haemolytic uraemic syndrome.非典型溶血尿毒综合征的眼部受累情况。
Arch Soc Esp Oftalmol. 2017 Dec;92(12):594-597. doi: 10.1016/j.oftal.2017.02.007. Epub 2017 Mar 24.
8
An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document.非典型溶血性尿毒症综合征的最新进展：诊断与治疗。一份共识文件。
Nefrologia. 2015;35(5):421-47. doi: 10.1016/j.nefro.2015.07.005. Epub 2015 Oct 9.
9
Rescue therapy with eculizumab in a transplant recipient with atypical haemolytic-uraemic syndrome.移植受者中补体因子 H 相关蛋白 5 自身抗体阳性的非典型溶血尿毒综合征采用依库珠单抗抢救治疗
Clin Kidney J. 2012 Feb;5(1):28-30. doi: 10.1093/ndtplus/sfr107. Epub 2012 Jan 28.
10
A kidney biopsy is clearly mandatory to confirm the indication of plasma exchanges in adult haemolytic uraemic syndrome.对于成人溶血性尿毒症综合征，进行肾脏活检显然是确认血浆置换指征的必要手段。
Ann Med Interne (Paris). 1994;145(5):369-72.

引用本文的文献

1
Eculizumab use in patients with pneumococcal-associated hemolytic uremic syndrome and kidney outcomes.依库珠单抗治疗肺炎球菌相关性溶血尿毒综合征患者的疗效及其对肾脏结局的影响。
Pediatr Nephrol. 2023 Dec;38(12):4209-4215. doi: 10.1007/s00467-023-06037-2. Epub 2023 Jun 12.
2
Complement C5 inhibition protects against hemolytic anemia and acute kidney injury in anthrax peptidoglycan-induced sepsis in baboons.补体 C5 抑制可预防狒狒炭疽肽聚糖诱导脓毒症中的溶血性贫血和急性肾损伤。
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37). doi: 10.1073/pnas.2104347118.
3
Streptococcus Pneumoniae-Associated Hemolytic Uremic Syndrome in the Era of Pneumococcal Vaccine.

本文引用的文献

1
Haemolytic uraemic syndrome.溶血尿毒综合征。
Lancet. 2017 Aug 12;390(10095):681-696. doi: 10.1016/S0140-6736(17)30062-4. Epub 2017 Feb 25.
2
Drug-induced thrombotic microangiopathy: a systematic review of published reports.药物诱导的血栓性微血管病：已发表报告的系统评价。
Blood. 2015 Jan 22;125(4):616-8. doi: 10.1182/blood-2014-11-611335. Epub 2014 Nov 20.
3
Trends in US hospital stays for Streptococcus pneumoniae-associated hemolytic uremic syndrome.美国医院中与肺炎链球菌相关溶血性尿毒症综合征相关的住院趋势。
肺炎球菌疫苗时代的肺炎链球菌相关性溶血尿毒综合征
Pathogens. 2021 Jun 9;10(6):727. doi: 10.3390/pathogens10060727.
4
-associated Thrombotic Microangiopathy in an Immunosuppressed Adult.免疫抑制成年患者相关的血栓性微血管病
Open Med (Wars). 2020 Mar 19;15:204-210. doi: 10.1515/med-2020-0030. eCollection 2020.
Pediatr Infect Dis J. 2013 Jul;32(7):731-5. doi: 10.1097/INF.0b013e31828b31c8.
4
The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome.补体在肺炎链球菌相关性溶血尿毒综合征中的作用。
Nephrol Dial Transplant. 2013 Sep;28(9):2237-45. doi: 10.1093/ndt/gft198. Epub 2013 Jun 19.
5
Does dysregulated complement activation contribute to haemolytic uraemic syndrome secondary to Streptococcus pneumoniae?补体激活失调是否与肺炎链球菌相关性溶血尿毒综合征有关？
Med Hypotheses. 2013 Sep;81(3):400-3. doi: 10.1016/j.mehy.2013.05.030. Epub 2013 Jun 17.
6
Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome.依库珠单抗治疗非典型溶血尿毒综合征。
N Engl J Med. 2013 Jun 6;368(23):2169-81. doi: 10.1056/NEJMoa1208981.
7
Adult hemolytic uremic syndrome associated with Streptococcus pneumoniae.成人溶血性尿毒症综合征与肺炎链球菌相关。
Clin Nephrol. 2014 Aug;82(2):144-8. doi: 10.5414/CN107796.
8
Streptococcus pneumoniae-associated hemolytic uremic syndrome in a splenectomized adult patient.一名脾切除成年患者的肺炎链球菌相关性溶血尿毒综合征
Intern Med. 2012;51(15):2001-5. doi: 10.2169/internalmedicine.51.7916. Epub 2012 Aug 1.
9
Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A.肺炎链球菌感染中 Thomssen-Friedenreich 抗原的暴露依赖于肺炎球菌神经氨酸酶 A。
Microb Pathog. 2011 Jun;50(6):343-9. doi: 10.1016/j.micpath.2011.02.010. Epub 2011 Mar 4.
10
Streptococcus pneumoniae-associated hemolytic uremic syndrome.肺炎链球菌相关的溶血尿毒综合征
Pediatr Nephrol. 2008 Nov;23(11):1951-6. doi: 10.1007/s00467-007-0518-y. Epub 2007 Jun 13.