Albritton W L, Penner S, Slaney L, Brunton J
J Clin Microbiol. 1978 Jun;7(6):519-23. doi: 10.1128/jcm.7.6.519-523.1978.
Based on a limited number of biochemical properties, a system for biotyping Haemophilus influenzae (M. Kilian, Acta Pathol. Microbiol, Scand. Sect. B82:835-842, 1976) was used to analyze the relationship of biotype to source of infection and antibiotic resistance for 600 clinical strains. The distribution of biotypes from bacteremic patients was significantly different (P less than 0.001) from the distribution of biotypes from nonbacteremic patients. Although there appeared to be a correlation between biotype and source of isolation, no single biotype correlated with a specific clinical syndrome in bacteremic patients. The frequency of resistance to antibiotics (ampicillin, tetracycline, chloramphenicol, and kanamycin), which was known to be at least in part plasmid mediated, was determined. Of the 600 isolates, 43 were resistant to at least one antibiotic (30 were ampicillin resistant, 11 were tetracycline resistant, 1 was ampicillin-tetracycline resistant, and 1 was tetracycline-chloramphenicol resistant). Of these 43 resistant isolates, 42 were either biotype I or II. This distribution of biotypes among antibiotic-resustant isolates was significantly different from the overall distribution of biotypes (P is less than 0.001).
基于有限的生化特性，采用一种对流感嗜血杆菌进行生物分型的系统（M. 基利安，《病理学与微生物学杂志，斯堪的纳维亚分册，B辑》82:835 - 842，1976年）对600株临床菌株的生物型与感染源及抗生素耐药性之间的关系进行分析。菌血症患者的生物型分布与非菌血症患者的生物型分布存在显著差异（P小于0.001）。虽然生物型与分离源之间似乎存在相关性，但在菌血症患者中没有单一生物型与特定临床综合征相关。测定了对已知至少部分由质粒介导的抗生素（氨苄青霉素、四环素、氯霉素和卡那霉素）的耐药频率。在这600株分离株中，43株对至少一种抗生素耐药（30株对氨苄青霉素耐药，11株对四环素耐药，1株对氨苄青霉素和四环素耐药，1株对四环素和氯霉素耐药）。在这43株耐药分离株中，42株为生物型I或II。抗生素耐药分离株中生物型的这种分布与生物型的总体分布存在显著差异（P小于0.001）。
