Han Xingting, Yang Dong, Yang Chuncheng, Spintzyk Sebastian, Scheideler Lutz, Li Ping, Li Dichen, Geis-Gerstorfer Jürgen, Rupp Frank
Section Medical Materials Science and Technology, University Hospital Tübingen, Osianderstr. 2⁻8, D-72076 Tübingen, Germany.
State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710054, China.
J Clin Med. 2019 Feb 12;8(2):240. doi: 10.3390/jcm8020240.
Fused deposition modeling (FDM) is a rapidly growing three-dimensional (3D) printing technology and has great potential in medicine. Polyether-ether-ketone (PEEK) is a biocompatible high-performance polymer, which is suitable to be used as an orthopedic/dental implant material. However, the mechanical properties and biocompatibility of FDM-printed PEEK and its composites are still not clear. In this study, FDM-printed pure PEEK and carbon fiber reinforced PEEK (CFR-PEEK) composite were successfully fabricated by FDM and characterized by mechanical tests. Moreover, the sample surfaces were modified with polishing and sandblasting methods to analyze the influence of surface roughness and topography on general biocompatibility (cytotoxicity) and cell adhesion. The results indicated that the printed CFR-PEEK samples had significantly higher general mechanical strengths than the printed pure PEEK (even though there was no statistical difference in compressive strength). Both PEEK and CFR-PEEK materials showed good biocompatibility with and without surface modification. Cell densities on the "as-printed" PEEK and the CFR-PEEK sample surfaces were significantly higher than on the corresponding polished and sandblasted samples. Therefore, the FDM-printed CFR-PEEK composite with proper mechanical strengths has potential as a biomaterial for bone grafting and tissue engineering applications.
熔融沉积成型（FDM）是一种快速发展的三维（3D）打印技术，在医学领域具有巨大潜力。聚醚醚酮（PEEK）是一种生物相容性高性能聚合物，适合用作骨科/牙科植入材料。然而，FDM打印的PEEK及其复合材料的机械性能和生物相容性仍不明确。在本研究中，通过FDM成功制备了FDM打印的纯PEEK和碳纤维增强PEEK（CFR-PEEK）复合材料，并进行了机械性能测试。此外，采用抛光和喷砂方法对样品表面进行改性，以分析表面粗糙度和形貌对一般生物相容性（细胞毒性）和细胞粘附的影响。结果表明，打印的CFR-PEEK样品的一般机械强度明显高于打印的纯PEEK（尽管抗压强度没有统计学差异）。PEEK和CFR-PEEK材料在有或没有表面改性的情况下均表现出良好的生物相容性。“打印后”的PEEK和CFR-PEEK样品表面的细胞密度明显高于相应的抛光和喷砂样品。因此，具有适当机械强度的FDM打印CFR-PEEK复合材料有潜力作为骨移植和组织工程应用的生物材料。
