Fottrell P F
Department of Biochemistry, University College, Galway, Ireland.
Br J Cancer Suppl. 1988 Dec;9:98-100.
The potential applications of measuring reproductive steroids in saliva were examined for investigating the basis of the lower prevalence of breast cancer and cancers of the reproductive system among former college athletes compared to non-athletes. Daily salivary progesterone measurements during the menstrual cycle by a rapid cost effective enzyme-immunoassay provided a more accurate method than established procedures for detecting abnormal ovarian function such as luteal phase defects. These abnormalities are common in athletes who have a later menarche, a higher incidence of oligomenorrhoea and amenorrhoea than non-athletes. A control corridor was established of upper and lower limits for normality of daily salivary progesterone values during the complete menstrual cycle in 42 volunteers. It is concluded that salivary steroid assays provide an accurate and non-invasive procedure suitable for long term comparative studies on ovarian steroids in female athletes and non-athletes before and after menarche.
为了探究前大学运动员相较于非运动员乳腺癌和生殖系统癌症患病率较低的原因，对唾液中生殖类固醇测量的潜在应用进行了研究。在月经周期中，通过一种快速且经济高效的酶免疫测定法每日测量唾液孕酮，与检测黄体期缺陷等异常卵巢功能的既定程序相比，提供了一种更准确的方法。这些异常在初潮较晚、月经稀发和闭经发生率高于非运动员的运动员中很常见。在42名志愿者的整个月经周期中，建立了每日唾液孕酮值正常范围的上下限控制通道。得出的结论是，唾液类固醇检测提供了一种准确且非侵入性的程序，适用于对女性运动员和非运动员初潮前后卵巢类固醇进行长期比较研究。
