Sensor Electronic & Instrumentation Group, Department of Physics, Faculty of Sciences, Moulay Ismaïl University, B.P. 11201, Zitoune, Meknes, Morocco; Biotechnology Agroalimentary and Biomedical Analysis Group, Department of Biology, Faculty of Sciences, Moulay Ismaïl University, B.P. 11201, Zitoune, Meknes, Morocco.
Nanostructurated Materials Laboratory, National R&D Institute for Non-Ferrous and Rare Metals, Pantelimon, Ilfov, Romania.
Sci Total Environ. 2019 May 10;664:647-658. doi: 10.1016/j.scitotenv.2019.01.331. Epub 2019 Jan 26.
Triclosan (TCS) is a topical antiseptic widely used in different cosmetic products. It is also a common additive in many antimicrobial household consumables. Over a certain concentration, it becomes risky for human and environmental health. This work describes the development of an electrochemical sensor based on molecularly imprinted polymer (MIP), assembled on screen-printed gold electrode (Au-SPE), dedicated to the TCS detection in environmental water sources. To achieve this goal, an acrylamide/bisacrylamide solution was polymerized after linking TCS with the carboxylic polyvinyl chloride (PVC-COOH) layer onto the Au-SPE. The sensor device fabrication and its retention capabilities were characterized through cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy. As control experiment, negligible responses were obtained during the non-imprinted polymer (NIP) test. The sensor could effectively detect TCS avoiding interferences of structural similar substances like 2,4,6-trichlorophenol and catechol. Under optimal conditions, the sensor responses were found logarithmic in the concentration range from 0.1 to 1000 pg mL. Indeed, compared with reported works, this sensor exhibits lower detection limit (LOD) and quantification limit (LOQ) of 0.23 and 0.78 pg mL, respectively. The developed sensor was effectively applied to wastewater samples for TCS detection and displayed satisfactory performances. Moreover, the different wastewater samples, regarding their TCS contents, were correctly classified by using principal component analysis (PCA) technique. Correspondingly, this work has demonstrated a cheap, simple and effective sensing platform for TCS detection thus making it a promising tool for future evolution of accurate and reliable environmental analysis.
三氯生（TCS）是一种广泛应用于不同化妆品的局部抗菌剂。它也是许多抗菌家用消费品的常见添加剂。超过一定浓度，它对人类和环境健康就会变得有风险。这项工作描述了一种基于分子印迹聚合物（MIP）的电化学传感器的开发，该传感器组装在丝网印刷金电极（Au-SPE）上，专门用于检测环境水源中的 TCS。为了实现这一目标，在 Au-SPE 上将 TCS 与羧酸聚氯乙烯（PVC-COOH）层连接后，聚合丙烯酰胺/双丙烯酰胺溶液。通过循环伏安法（CV）、差分脉冲伏安法（DPV）、电化学阻抗谱（EIS）、原子力显微镜（AFM）和傅里叶变换红外（FTIR）光谱对传感器装置的制造及其保留能力进行了表征。作为对照实验，在非印迹聚合物（NIP）测试中几乎没有得到响应。该传感器可以有效地检测 TCS，避免了结构相似物质（如 2,4,6-三氯苯酚和儿茶酚）的干扰。在最佳条件下，传感器的响应在 0.1 至 1000 pg mL 的浓度范围内呈对数关系。实际上，与已报道的工作相比，该传感器的检测限（LOD）和定量限（LOQ）分别为 0.23 和 0.78 pg mL。所开发的传感器有效地应用于废水样品中 TCS 的检测，并显示出令人满意的性能。此外，通过使用主成分分析（PCA）技术，可以正确地对不同废水样品进行分类，以确定它们的 TCS 含量。相应地，这项工作展示了一种用于 TCS 检测的廉价、简单和有效的传感平台，因此有望成为未来准确可靠的环境分析的工具。
