Sekhon Harmehr, Launay Cyrille P, Chabot Julia, Allali Gilles, Beauchet Olivier
Division of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis - Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada.
Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Front Aging Neurosci. 2019 Jan 23;10:434. doi: 10.3389/fnagi.2018.00434. eCollection 2018.
Slow walking speed, time to perform the five-times-sit-to-stand (FTSS) test and motoric cognitive risk syndrome (MCR; defined as slow gait speed combined with subjective cognitive complaint) have been separately used to screen older individuals at risk of cognitive decline. This study seeks to (1) compare the characteristics of older individuals with MCR, as defined through slow walking speed and/or increased FTSS time; and (2) examine the relationship between MCR and its motor components as well as amnestic (a-MCI) and non-amnestic (na-MCI) Mild Cognitive Impairment. A total of 633, individuals free of dementia, were selected from the cross-sectional "Gait and Alzheimer Interactions Tracking" study. Slow gait speed and increased FTSS time were used as criteria for the definition of MCR. Participants were separated into five groups, according to MCR status: MCR as defined by (1) slow gait speed exclusively (MCRs); (2) increased FTSS time exclusively (MCRf); (3) slow gait speed and increased FTSS time (MCRsaf); (4) MCR; irrespective of the mobility test used (MCRsof); and (5) the absence of MCR. Cognitive status (i.e., a-MCI, na-MCI, cognitively healthy) was also determined. The prevalence of MCRs was higher, when compared to the prevalence of MCRf (12.0% versus 6.2% with ≤ 0.001). There existed infrequent overlap (2.4%) between individuals exhibiting MCRs and MCRf, and frequent overlap between individuals exhibiting MCRs and na-MCI (up to 50%). a-MCI and na-MCI were negatively [odd ratios (OR) ≤ 0.17 with ≤ 0.019] and positively (OR ≥ 2.41 with ≤ 0.019) related to MCRs, respectively. Individuals with MCRf are distinct from those with MCRs. MCRf status does not relate to MCI status in the same way that MCRs does. MCRs is related negatively to a-MCI and positively to na-MCI. These results suggest that FTTS cannot be used to define MCR when the goal is to predict the risk of cognitive decline, such as future dementia.
步速缓慢、完成五次坐立试验（FTSS）的时间以及运动认知风险综合征（MCR；定义为步态缓慢并伴有主观认知主诉）已分别用于筛查有认知能力下降风险的老年人。本研究旨在：（1）比较通过步速缓慢和/或FTSS时间增加所定义的患有MCR的老年人的特征；（2）研究MCR与其运动成分以及遗忘型（a-MCI）和非遗忘型（na-MCI）轻度认知障碍之间的关系。从横断面的“步态与阿尔茨海默病相互作用追踪”研究中选取了633名无痴呆症的个体。步速缓慢和FTSS时间增加被用作定义MCR的标准。根据MCR状态，参与者被分为五组：（1）仅由步速缓慢定义的MCR（MCRs）；（2）仅由FTSS时间增加定义的MCR（MCRf）；（3）步速缓慢且FTSS时间增加（MCRsaf）；（4）无论使用何种运动测试的MCR（MCRsof）；以及（5）无MCR。还确定了认知状态（即a-MCI、na-MCI、认知健康）。与MCRf的患病率相比，MCRs的患病率更高（12.0%对6.2%，P≤0.001）。表现出MCRs和MCRf的个体之间存在罕见的重叠（2.4%），而表现出MCRs和na-MCI的个体之间存在频繁的重叠（高达50%）。a-MCI和na-MCI分别与MCRs呈负相关（比值比[OR]≤0.17，P≤0.019）和正相关（OR≥2.41，P≤0.019）。患有MCRf的个体与患有MCRs的个体不同。MCRf状态与MCI状态的关系与MCRs不同。MCRs与a-MCI呈负相关，与na-MCI呈正相关。这些结果表明，当目标是预测认知能力下降（如未来痴呆症）的风险时，FTTS不能用于定义MCR。
