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蜂胶制剂对研究中跨上皮电位、电阻和离子转运的影响。

Effect of Propolis Preparations on Transepithelial Electrical Potential, Resistance, and Ion Transport in Study.

作者信息

Smyk Paulina, Hołyńska-Iwan Iga, Olszewska-Słonina Dorota

机构信息

Department of Pediatric Nursing, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Poland.

Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Poland.

出版信息

Evid Based Complement Alternat Med. 2019 Jan 15;2019:3756092. doi: 10.1155/2019/3756092. eCollection 2019.

DOI:10.1155/2019/3756092
PMID:30766612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6350614/
Abstract

BACKGROUND

Propolis and its ethanol extract show positive germicidal, bacteriostatic, and anti-inflammatory antioxidants and regenerative properties after use on the surface of the skin. Propolis is in common use in production of cosmetics and in folk medicine. The influence of this resinous mixture on ion channels, channels located in skin cells membranes and skin electrical resistance, was not explained.

OBJECTIVE

The main aim of the study was the evaluation of electrophysiological skin parameters during mechanical and chemical-mechanical stimulation after use of ethanol extract of propolis and propolis ointment in comparison with iso-osmotic Ringer solution.

METHODS

Skin fragments were taken from white New Zealand rabbits and distributed into three experimental groups which were incubated in ethanol extract of propolis (EEP), propolis ointment, and Ringer solution. Then they were placed in a Ussing chamber to measure electrophysiological parameters values.

RESULTS

In this study the influence of EEP on changes in value of electrical potential during block of chloride ions transport at the same time was observed. Ethanol propolis extract dissolved in water increases the transepidermal sodium ions transport in contrast to propolis ointment.

CONCLUSION

The way of preparation cosmetics, which contain propolis, has effects on transepidermal ions transport in the rabbit's skin. The value of skin electrical resistance is changing with penetration depth of active propolis substances contained in cosmetics.

摘要

背景

蜂胶及其乙醇提取物在用于皮肤表面后显示出积极的杀菌、抑菌、抗炎抗氧化和再生特性。蜂胶常用于化妆品生产和民间医学。这种树脂混合物对离子通道、位于皮肤细胞膜中的通道以及皮肤电阻的影响尚未得到解释。

目的

本研究的主要目的是评估与等渗林格溶液相比，使用蜂胶乙醇提取物和蜂胶软膏后在机械和化学 - 机械刺激期间的皮肤电生理参数。

方法

从白色新西兰兔身上获取皮肤碎片，并分为三个实验组，分别在蜂胶乙醇提取物（EEP）、蜂胶软膏和林格溶液中孵育。然后将它们置于尤斯灌流小室中测量电生理参数值。

结果

在本研究中，观察到EEP对氯离子转运受阻时电位值变化的影响。与蜂胶软膏相比，溶于水的蜂胶乙醇提取物增加了经表皮钠离子转运。

结论

含有蜂胶的化妆品的制备方式对兔皮肤中的经表皮离子转运有影响。皮肤电阻值随化妆品中活性蜂胶物质的渗透深度而变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/1ac22c012613/ECAM2019-3756092.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/d2c564c7b3f8/ECAM2019-3756092.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/a3d86a188be2/ECAM2019-3756092.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/3962a4ea63ed/ECAM2019-3756092.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/422e3b11e9a6/ECAM2019-3756092.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/06632817ff31/ECAM2019-3756092.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/1ac22c012613/ECAM2019-3756092.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/d2c564c7b3f8/ECAM2019-3756092.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/a3d86a188be2/ECAM2019-3756092.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/3962a4ea63ed/ECAM2019-3756092.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/422e3b11e9a6/ECAM2019-3756092.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/06632817ff31/ECAM2019-3756092.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/6350614/1ac22c012613/ECAM2019-3756092.006.jpg

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2
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Adv Physiol Educ. 2017 Sep 1;41(3):444-447. doi: 10.1152/advan.00115.2016.
3
Biological properties of propolis extracts: Something new from an ancient product.蜂胶提取物的生物学特性：古老产品中的新发现。
Chem Phys Lipids. 2017 Oct;207(Pt B):214-222. doi: 10.1016/j.chemphyslip.2017.04.005. Epub 2017 Apr 12.
4
Bioactive properties of honey with propolis.蜂蜜与蜂胶的生物活性特性。
Food Chem. 2016 Apr 1;196:1215-23. doi: 10.1016/j.foodchem.2015.10.050. Epub 2015 Oct 23.
5
Alternative preparation of propolis extracts: comparison of their composition and biological activities.蜂胶提取物的替代制备方法：其成分与生物活性的比较。
BMC Complement Altern Med. 2015 May 27;15:156. doi: 10.1186/s12906-015-0677-5.
6
Propolis: a review of properties, applications, chemical composition, contact allergy, and other adverse effects.蜂胶：性质、应用、化学成分、接触过敏和其他不良反应的综述。
Dermatitis. 2013 Nov-Dec;24(6):263-82. doi: 10.1097/DER.0000000000000011.
7
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Evid Based Complement Alternat Med. 2013;2013:356737. doi: 10.1155/2013/356737. Epub 2013 May 23.
8
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Evid Based Complement Alternat Med. 2013;2013:590703. doi: 10.1155/2013/590703. Epub 2013 Apr 10.
9
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10
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Z Naturforsch C J Biosci. 2012 Nov-Dec;67(11-12):545-50. doi: 10.1515/znc-2012-11-1203.