Zeng Xiaoyu, Lv Ying, Gu Zhongxiu, Jia Zhe, Zhang Chen, Lu Xiaoxiao, Chu Chenchen, Gao Yichen, Nie Yu, Wang Yanxia, Zhang Yan, Zhao Shaozhen
Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, College of Optometry and Ophthalmology, Tianjin Medical University, Tianjin 300384, China.
J Ophthalmol. 2019 Jan 10;2019:8127515. doi: 10.1155/2019/8127515. eCollection 2019.
To observe ocular surface changes in Type II diabetic patients with different disease durations and to understand the correlations between clinical parameters and diabetic durations.
In this cross-sectional, prospective study, 51 healthy controls and 91 patients with Type II diabetes were enrolled. The diabetics were divided into 3 subgroups according to the disease duration, including duration <10 y group, 10 to 20 y group, and ≥21 y group. All subjects underwent clinical ocular examinations, including lipid layer thickness (LLT), blinking rate, tear meniscus height (TMH), noninvasive tear film break-up time (NI-BUT), meibography, superficial punctate keratopathy (SPK) scoring, corneal sensitivity, and Schirmer I test. They were also evaluated using the standard patient evaluation of eye dryness (SPEED) questionnaire.
SPEED score, meiboscore, SPK score, LLT, Schirmer I test, and corneal sensitivity differed significantly between the diabetic and healthy control groups. Further, SPEED score, Schirmer I test, corneal sensitivity, meiboscore, and blink rate significantly differed among the 3 diabetic subgroups and the control group. In diabetics, the SPEED score correlated with the SPK score, blink rate, TMH, and LLT; NI-BUT with TMH, LLT, and blink rate; TMH with the SPK score; Schirmer I test with the SPK score; and corneal sensitivity with the meiboscore. More importantly, the Schirmer I test, corneal sensitivity, and SPEED score negatively correlated with diabetic duration.
Diabetic duration is an important factor that affects functions of the lacrimal functional unit in patients with Type II diabetes. The trends of changes in the ocular parameters vary along the course of diabetes.
观察不同病程的2型糖尿病患者的眼表变化，并了解临床参数与糖尿病病程之间的相关性。
在这项横断面前瞻性研究中，纳入了51名健康对照者和91名2型糖尿病患者。糖尿病患者根据病程分为3个亚组，包括病程<10年组、10至20年组和≥21年组。所有受试者均接受临床眼部检查，包括脂质层厚度（LLT）、眨眼频率、泪河高度（TMH）、无创泪膜破裂时间（NI-BUT）、睑板腺照相、浅层点状角膜炎（SPK）评分、角膜敏感性和Schirmer I试验。还使用标准干眼患者评估（SPEED）问卷对他们进行评估。
糖尿病组和健康对照组之间的SPEED评分、睑板腺评分、SPK评分、LLT、Schirmer I试验和角膜敏感性存在显著差异。此外，3个糖尿病亚组与对照组之间的SPEED评分、Schirmer I试验、角膜敏感性、睑板腺评分和眨眼频率也存在显著差异。在糖尿病患者中，SPEED评分与SPK评分、眨眼频率、TMH和LLT相关；NI-BUT与TMH、LLT和眨眼频率相关；TMH与SPK评分相关；Schirmer I试验与SPK评分相关；角膜敏感性与睑板腺评分相关。更重要的是，Schirmer I试验、角膜敏感性和SPEED评分与糖尿病病程呈负相关。
糖尿病病程是影响2型糖尿病患者泪液功能单位功能的重要因素。眼部参数的变化趋势随糖尿病病程而变化。
