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一项随机对照试验:针对有自杀倾向的青少年的基于依恋的家庭和非直接支持性治疗。

A Randomized Controlled Trial: Attachment-Based Family and Nondirective Supportive Treatments for Youth Who Are Suicidal.

机构信息

Center for Family Intervention Science, Drexel University, Philadelphia, PA.

University of Delaware, Newark.

出版信息

J Am Acad Child Adolesc Psychiatry. 2019 Jul;58(7):721-731. doi: 10.1016/j.jaac.2018.10.006. Epub 2018 Oct 30.

Abstract

OBJECTIVE

To evaluate the efficacy of attachment-based family therapy (ABFT) compared with a family-enhanced nondirective supportive therapy (FE-NST) for decreasing adolescents' suicide ideation and depressive symptoms.

METHOD

A randomized controlled trial of 129 adolescents who are suicidal ages 12- to 18-years-old (49% were African American) were randomized to ABFT (n = 66) or FE-NST (n = 63) for 16 weeks of treatment. Assessments occurred at baseline and 4, 8, 12, and 16 weeks. Trajectory of change and clinical recovery were calculated for suicidal ideation and depressive symptoms.

RESULTS

There was no significant between-group difference in the rate of change in self-reported ideation (Suicidal Ideation Questionnaire-Jr; F = 181, p = .18). Similar results were found for depressive symptoms. However, adolescents receiving ABFT showed a significant decrease in suicide ideation (t = 12.61, p < .0001; effect size, d = 2.24). Adolescents receiving FE-NST showed a similar significant decrease (t = 10.88, p < .0001; effect size, d = 1.93). Response rates (ie, ≥50% decrease in suicide ideation symptoms from baseline) at post-treatment were 69.1% for ABFT versus 62.3% for FE-NST.

CONCLUSION

Contrary to expectations, ABFT did not perform better than FE-NST. The 2 treatments produced substantial decreases in suicidal ideation and depressive symptoms that were comparable to or better than those reported in other more intensive, multicomponent treatments. The equivalent outcomes could be attributed to common treatment elements, different active mechanisms, or regression to the mean. Future studies will explore long-term follow up, secondary outcomes, and potential moderators and mediators.

CLINICAL TRIAL REGISTRATION INFORMATION

Attachment-Based Family Therapy for Suicidal Adolescents; http://clinicaltrials.gov; NCT01537419.

摘要

目的

评估基于依恋的家庭治疗(ABFT)与增强型非直接支持性家庭治疗(FE-NST)相比,降低青少年自杀意念和抑郁症状的疗效。

方法

对 129 名年龄在 12 至 18 岁(49%为非裔美国人)有自杀倾向的青少年进行了一项随机对照试验,他们被随机分配到 ABFT(n=66)或 FE-NST(n=63)组,接受为期 16 周的治疗。评估在基线、4、8、12 和 16 周时进行。计算自杀意念和抑郁症状的变化轨迹和临床恢复情况。

结果

在自我报告的意念变化率方面,两组之间没有显著差异(青少年自杀意念问卷 Jr;F=181,p=0.18)。抑郁症状也得出了类似的结果。然而,接受 ABFT 的青少年自杀意念显著下降(t=12.61,p<0.0001;效应大小,d=2.24)。接受 FE-NST 的青少年也显示出类似的显著下降(t=10.88,p<0.0001;效应大小,d=1.93)。治疗后,ABFT 的反应率(即自杀意念症状较基线下降≥50%)为 69.1%,FE-NST 为 62.3%。

结论

与预期相反,ABFT 并不优于 FE-NST。两种治疗方法都显著降低了自杀意念和抑郁症状,与其他更密集、多成分治疗报告的结果相当或更好。同等的结果可能归因于共同的治疗要素、不同的积极机制或回归均值。未来的研究将探索长期随访、次要结果以及潜在的调节和中介因素。

临床试验注册信息

依恋为基础的家庭治疗对自杀青少年;http://clinicaltrials.gov;NCT01537419。

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