Nascimento Bruno F O, Pereira Nelson A M, Valente Artur J M, Pinho E Melo Teresa M V D, Pineiro Marta
CQC and Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.
Pharmaceutics. 2019 Feb 15;11(2):81. doi: 10.3390/pharmaceutics11020081.
Porphyrins are known therapeutic agents for photodynamic therapy of cancer and also imaging agents for NIR fluorescence imaging, MRI, or PET. A combination of interesting features makes tetrapyrrolic macrocycles suitable for use as theranostic agents whose full potential can be achieved using nanocarriers. This review provides an overview on nanotheranostic agents based on polymeric micelles and porphyrins developed so far.
卟啉是已知的用于癌症光动力疗法的治疗剂，也是用于近红外荧光成像、磁共振成像或正电子发射断层扫描的成像剂。一系列有趣的特性使四吡咯大环适合用作治疗诊断剂，而使用纳米载体可充分发挥其全部潜力。本文综述了迄今为止基于聚合物胶束和卟啉开发的纳米治疗诊断剂。
