Rybka Jakub Dalibor
Center for Advanced Technology, Adam Mickiewicz University, Poznan, Poland.
Rep Pract Oncol Radiother. 2019 Mar-Apr;24(2):152-157. doi: 10.1016/j.rpor.2019.01.002. Epub 2019 Feb 6.
Melanoma is responsible for the majority of deaths related to skin cancer. Worryingly, prognoses show an increasing number of melanoma cases each year worldwide. Radiotherapy, which is a cornerstone of cancer treatment, has proved to be useful but insufficient in melanoma management due to exceptionally high radioresistance of melanoma cells. This problem could be overcome by superparamagnetic iron oxide nanoparticles (SPIONs) used as heat mediators in magnetic hyperthermia, which not only enhance radiosensitivity, but also enable precise targeting by exploitation of their magnetic properties.
黑色素瘤是导致大多数皮肤癌相关死亡的原因。令人担忧的是，预后显示全球每年黑色素瘤病例的数量在不断增加。放射治疗是癌症治疗的基石，已被证明是有用的，但由于黑色素瘤细胞具有极高的放射抗性，在黑色素瘤治疗中还不够充分。通过在磁热疗中用作热介质的超顺磁性氧化铁纳米颗粒（SPIONs）可以克服这个问题，这些纳米颗粒不仅能增强放射敏感性，还能利用其磁性实现精确靶向。
