直肠癌患者从II级到III级转变的网络分析。
Network analysis of grade II into grade III transition in rectum cancer patients.
作者信息
Rostami-Nejad Mohammad, Mansouri Vahid, Mahmoud Robati Reza, Mohaghegh Shalmani Hamid, Mahmoudi Lamouki Reza, Rezaei Tavirani Mostafa
机构信息
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2018 Winter;11(Suppl 1):S118-S123.
AIM
Finding important differential genes between grade II and grade III of rectum cancer was the aim of this study.
BACKGROUND
Colorectal (CRC) cancers (CRC) are known as the third diagnosed cancer and the second leading to death cancers. Life style is an important risk factor of CRCs. Diagnosis of rectum cancer estimated as 44% of colon cancer.
METHODS
Differentially expressed genes (DEGS) related to grade II into grade II in 6 patients are retrieved from gene expression omnibus (GEO) and investigated by protein-protein interaction (PPI) network analysis. Central nodes of the network are identified and enriched to determine biochemical pathways. Action map is illustrated for the central genes.
RESULTS
Among 15 central genes including AKT1, PRDM10, GAPDH, TP53, SRC, EGFR, ALB, INS, CTNNB1, EGF, IL6, RHOA, DECR1, ACACA, GMPS role of AKT1 is highlighted due to prominent role in the integrity of the network and participation in the most determined pathways. However, significant regulatory effect of INS, AKT1, EGF, EGFR, and CTNNB1 is tinted in action map.
CONCLUSION
It seems that AKT1, EGFR, and TP3 are suitable drug targets to prevent rectum cancer progression.
目的
本研究的目的是寻找直肠癌II级和III级之间的重要差异基因。
背景
结直肠癌（CRC）是第三大诊断出的癌症，也是导致死亡的第二大癌症。生活方式是结直肠癌的一个重要风险因素。直肠癌的诊断估计占结肠癌的44%。
方法
从基因表达综合数据库（GEO）中检索6例患者中与直肠癌II级到III级相关的差异表达基因（DEGs），并通过蛋白质-蛋白质相互作用（PPI）网络分析进行研究。识别并富集网络的中心节点以确定生化途径。为中心基因绘制作用图。
结果
在包括AKT1、PRDM10、GAPDH、TP53、SRC、EGFR、ALB、INS、CTNNB1、EGF、IL6、RHOA、DECR1、ACACA、GMPS在内的15个中心基因中，AKT1的作用因在网络完整性中的突出作用以及参与最确定的途径而受到关注。然而，INS、AKT1、EGF、EGFR和CTNNB1在作用图中显示出显著的调节作用。
结论
似乎AKT1、EGFR和TP3是预防直肠癌进展的合适药物靶点。
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