拓展光驱动过氧合酶反应的光谱范围。

Willot Sébastien J-P, Fernández-Fueyo Elena, Tieves Florian, Pesic Milja, Alcalde Miguel, Arends Isabel W C E, Park Chan Beum, Hollmann Frank

Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.

Department of Biocatalysis, Institute of Catalysis, CSIC, 28049 Madrid, Spain.

ACS Catal. 2019 Feb 1;9(2):890-894. doi: 10.1021/acscatal.8b03752. Epub 2018 Dec 18.

Peroxygenases require a controlled supply of HO to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O to produce HO which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.

过氧酶需要可控的过氧化氢供应才能高效运作。在此，我们提出一种用于将环境中的氧气还原活化以产生过氧化氢的光催化系统，该系统基于波长互补的光敏剂组合，能更有效地利用可见光提供的能量。这种方法与一种酶系统相结合，以使甲酸盐作为牺牲电子供体可用。本文报道并讨论了这种方法的适用范围和当前局限性。