Quidim Alessandra V L, Bruno Tatiana, Leocádio Paola Caroline Lacerda, Santos Itamar S, Alvarez-Leite Jacqueline Isaura, Dos Reis Menta Penélope Lacrísio, Lotufo Paulo A, Benseñor Isabela M, Goulart Alessandra C
Center of Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, Brazil.
Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Brazil.
Clin Biochem. 2019 Apr;66:37-43. doi: 10.1016/j.clinbiochem.2019.02.006. Epub 2019 Feb 15.
We aimed to analyze the association of nitrotyrosine (N-TYR) levels and long-term survival in an ongoing coronary heart disease (CHD) prospective cohort, the Acute Coronary Syndrome Registry Strategy (ERICO study).
N-TYR levels collected during acute and subacute phase from onset of acute coronary syndrome (ACS) symptoms (myocardial infarction and unstable angina) were evaluated in 342 patients. We calculated case-fatality rates (180-days, 1 year, 2 years and 4 years) and survival analyses up to 4 years using Kaplan-Meier curves and Cox regression with respective cumulative hazard ratios (95% confidence interval; 95%CI), according to N-TYR tertiles up to 4 years of follow-up. Models are presented as crude, age and sex-adjusted and further adjusted for lipids and other confounders.
Overall, median level of N-TYR was 208.33 nmol/l (range: 3.09 to 1500 nmol/l), regardless ACS subtype. During follow-up of 4 years, we observed 44 (12.9%) deaths. Overall survival rate was 298 (87.1%) (Survival days: 1353, 95%CI: 1320-1387 days). N-TYR levels did not associate with mortality / survival rates up to 4 years.
No relationship was found between N-TYR levels and mortality rates after ACS during 4-year follow-up in the ERICO study.
我们旨在分析正在进行的冠心病（CHD）前瞻性队列研究——急性冠状动脉综合征登记策略（ERICO研究）中硝基酪氨酸（N-TYR）水平与长期生存之间的关联。
对342例急性冠状动脉综合征（ACS）症状（心肌梗死和不稳定型心绞痛）发作时急性和亚急性期采集的N-TYR水平进行评估。我们根据随访4年期间的N-TYR三分位数，使用Kaplan-Meier曲线和Cox回归计算病例死亡率（180天、1年、2年和4年）以及长达4年的生存分析，并计算各自的累积风险比（95%置信区间；95%CI）。模型以粗模型、年龄和性别调整模型以及进一步调整脂质和其他混杂因素的模型呈现。
总体而言，无论ACS亚型如何，N-TYR的中位水平为208.33 nmol/l（范围：3.09至1500 nmol/l）。在4年的随访期间，我们观察到44例（12.9%）死亡。总生存率为298例（87.1%）（生存天数：1353天，95%CI：1320 - 1387天）。N-TYR水平与长达4年的死亡率/生存率无关。
在ERICO研究中，4年随访期间未发现ACS后N-TYR水平与死亡率之间存在关联。
