Basnet Buddha Bahadur, Liu Li, Chen Baosong, Suleimen Yerlan Melsuly, Yu Haiyang, Guo Shouyu, Bao Li, Ren Jinwei, Liu Hongwei
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.
International College, University of Chinese Academy of Sciences, Beijing, China.
Planta Med. 2019 Jul;85(9-10):701-707. doi: 10.1055/a-0855-4051. Epub 2019 Feb 19.
Two new arborinane-type triterpenes, myrotheols A (1: ) and B (2: ), two new arborinane-type glycosides, myrothesides C (3: ) and D (4: ), together with four known diterpenes (5: - 8: ) were isolated from the ethyl acetate extract of the endolichenic fungus . The structures of new compounds 1: - 4: were elucidated by NMR and MS analyses. The absolute configuration of 1: was assigned by a single-crystal X-ray diffraction experiment. Compounds 3: and 4: represent the first two natural 4-O-methyl--D-mannosides. Compounds 1: - 8: exhibited cytotoxicity against K562 and RKO human cancer cell lines.
从内生地衣真菌的乙酸乙酯提取物中分离出两种新的乔木烷型三萜，即肉棒菌醇A（1: ）和B（2: ），两种新的乔木烷型糖苷，即肉棒菌苷C（3: ）和D（4: ），以及四种已知的二萜（5: - 8: ）。通过核磁共振（NMR）和质谱（MS）分析阐明了新化合物1: - 4: 的结构。通过单晶X射线衍射实验确定了1: 的绝对构型。化合物3: 和4: 是前两个天然的4-O-甲基-β-D-甘露糖苷。化合物1: - 8: 对K562和RKO人癌细胞系表现出细胞毒性。
