Lee Jin-Ho, Park Soo-Jeong, Choi Jeong-Woo
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Korea.
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Nanomaterials (Basel). 2019 Feb 20;9(2):297. doi: 10.3390/nano9020297.
Graphene, a single atom thick layer of two-dimensional closely packed honeycomb carbon lattice, and its derivatives have attracted much attention in the field of biomedical, due to its unique physicochemical properties. The valuable physicochemical properties, such as high surface area, excellent electrical conductivity, remarkable biocompatibility and ease of surface functionalization have shown great potentials in the applications of graphene-based bioelectronics devices, including electrochemical biosensors for biomarker analysis. In this review, we will provide a selective overview of recent advances on synthesis methods of graphene and its derivatives, as well as its application to electrochemical biosensor development. We believe the topics discussed here are useful, and able to provide a guideline in the development of novel graphene and on graphene-like 2-dimensional (2D) materials based biosensors in the future.
石墨烯是由二维紧密堆积的蜂窝状碳原子晶格构成的单原子厚层，由于其独特的物理化学性质，石墨烯及其衍生物在生物医学领域备受关注。诸如高表面积、优异的导电性、显著的生物相容性以及易于进行表面功能化等宝贵的物理化学性质，在基于石墨烯的生物电子器件应用中展现出了巨大潜力，包括用于生物标志物分析的电化学生物传感器。在本综述中，我们将对石墨烯及其衍生物的合成方法以及在电化学生物传感器开发中的应用的最新进展进行选择性概述。我们相信这里讨论的主题是有用的，并且能够为未来新型石墨烯及类石墨烯二维（2D）材料基生物传感器的开发提供指导。
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