阿西尔地区传统药用植物精油对耐药分离株的抗菌效率。
Antimicrobial Efficiency of Essential Oils from Traditional Medicinal Plants of Asir Region, Saudi Arabia, over Drug Resistant Isolates.
机构信息
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Atomic Energy Authority, Nuclear Research Center, Plant Researches Department, P.N. 13759, Egypt.
出版信息
Biomed Res Int. 2019 Jan 17;2019:8928306. doi: 10.1155/2019/8928306. eCollection 2019.
Abstract
Antimicrobial resistance (AMR) is a recurring global problem, which constantly demands new antimicrobial compounds to challenge the resistance. It is well known that essential oils (EOs) have been known for biological activities including antimicrobial properties. In this study, EOs from seven aromatic plants of Asir region of southwestern Saudi Arabia were tested for their antimicrobial efficacy against four drug resistant pathogenic bacterial isolates ( and and one fungal isolate (. Chemical compositions of EOs were determined by gas chromatography-mass spectrometry (GC-MS). The results revealed that EOs from , and proved most active against all isolates with inhibitory zone range between 17 and 45 mm. The lowest minimum inhibitory concentration (MIC) of 0.025mg/ml was observed for and with EO of . All the three EOs showed significant anticandida activity. The results related to EOs from , and demonstrated significant antimicrobial efficacy against drug resistant microorganisms.
摘要
抗微生物药物耐药性（AMR）是一个反复出现的全球性问题，不断需要新的抗微生物化合物来挑战耐药性。众所周知，精油（EOs）具有包括抗菌特性在内的生物活性。在这项研究中，测试了来自沙特阿拉伯西南部阿西尔地区的七种芳香植物的精油对四种耐药性致病性细菌分离株（ 和 和一种真菌分离株（ 的抗菌功效。通过气相色谱-质谱联用（GC-MS）测定了精油的化学成分。结果表明， 和 的精油对所有分离株均表现出最活跃的抗菌活性，抑菌圈范围在 17 到 45mm 之间。 和 的精油对 的最低最小抑菌浓度（MIC）为 0.025mg/ml。三种精油均表现出显著的抗假丝酵母菌活性。 和 的精油的结果表明，它们对耐药性微生物具有显著的抗菌功效。
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