Department of Clinical Acupuncture and Moxibustion, Nanjing University of Chinese Medicine, Nanjing, China.
Italian Federation of Acupuncture Societies (FISA), Association of Medical Acupuncturists of Bologna (A.M.A.B.), Bologna, Italy.
BMJ Open. 2019 Feb 22;8(11):e022998. doi: 10.1136/bmjopen-2018-022998.
Although the effectiveness of acupuncture for episodic migraine has been confirmed by multiple clinical trials and Cochrane systematic reviews, the mechanisms underlying the specific effect of acupuncture for migraine remain controversial. We aim to evaluate the effectiveness and safety of acupuncture for both episodic migraine and chronic migraine by meta-analysis and explore the possible factors influencing the specific effect of acupuncture for migraine by meta-regression.
We will search for randomised control trials of acupuncture for migraine in the following eight databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, AMED (via OVID) and four Chinese databases (Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database and Wanfang Database) from inception to 31 December 2017. We will also search OpenSIGLE (opensigle.inist.fr) for conference abstracts. No language restriction will be applied. The selection of studies, data extraction and coding and assessment of risk of bias of the included studies will be conducted independently by two reviewers. Standard meta-analysis and, if appropriate, meta-regression will be performed using the R packages Meta and Metafor.
The results of this meta-analysis and meta-regression will be disseminated through publication in a peer-reviewed journal and presented at a relevant conference. The data used in this meta-analysis will not contain individual patient data; therefore, ethical approval is not required.
CRD42018087270.
虽然多项临床试验和 Cochrane 系统评价已经证实了针灸治疗发作性偏头痛的有效性，但针灸治疗偏头痛的具体作用机制仍存在争议。我们旨在通过荟萃分析评估针灸治疗发作性偏头痛和慢性偏头痛的疗效和安全性，并通过荟萃回归探索可能影响针灸治疗偏头痛具体作用的因素。
我们将从八个数据库中搜索针灸治疗偏头痛的随机对照试验：Cochrane 对照试验中心注册库（CENTRAL）、MEDLINE、EMBASE、AMED（通过 OVID）和四个中文数据库（中国生物医学文献数据库、中国国家知识基础设施、中国科技期刊数据库和万方数据库），检索时间为建库至 2017 年 12 月 31 日。我们还将在 OpenSIGLE（opensigle.inist.fr）中搜索会议摘要。不限制语言。研究的选择、数据提取和编码以及纳入研究的偏倚风险评估将由两名评审员独立进行。将使用 R 包 Meta 和 Metafor 进行标准荟萃分析，如果合适，还将进行荟萃回归。
本荟萃分析和荟萃回归的结果将通过在同行评议期刊上发表和在相关会议上展示来传播。本荟萃分析中使用的数据不包含个体患者数据；因此，不需要伦理批准。
PROSPERO 注册号：CRD42018087270。
