Varejão Cristiane da Silva, Santo Fátima H do Espírito
1 Cancer Chemotherapy Center of the National Cancer Institute, Rio de Janeiro, RJ, Brazil.
2 Aurora de Afonso Costa School of Nursing, Fluminense Federal University, (MPEA/EEAAC/UFF), Niterói, RJ, Brazil.
J Pediatr Oncol Nurs. 2019 Jan/Feb;36(1):44-54. doi: 10.1177/1043454218810140.
Nausea and vomiting are frequent side effects associated with chemotherapy treatments. The aim of this study was to evaluate the efficacy of laser acupuncture in relieving nausea and vomiting in children and adolescents undergoing laser treatment. This is an experimental, randomized, single-blind study. The research was carried out at the INCA (Instituto Nacional de Câncer), a reference institution in the control and treatment of cancer, located in the city of Rio de Janeiro, Brazil. The research project was approved by the INCA Research and Ethics Committee under Registration No. 164/14 and CAAE 3374551.0.3001.5274. Children and adolescents between the ages of 6 and 17 years who were undergoing chemotherapy with drugs of high and medium degrees of emetogenic toxicity were selected. The participants were divided into two groups, A and B. In A, the active acupuncture was applied, and in B, the placebo acupuncture was applied. Analysis of the data indicated that there was significant relief from nausea in the intervention group when compared with the placebo group. A decrease in the number of episodes of vomiting on the second and third days of chemotherapy was also observed. On Days 1, 4, and 5, there was no significant difference in the number of episodes of vomiting in the intervention group as compared with the placebo group. The study concluded that laser acupuncture was effective in relieving nausea within 5 days of chemotherapy and in reducing the number of episodes of vomiting on Days 2 and 3 after chemotherapy.
恶心和呕吐是化疗治疗常见的副作用。本研究的目的是评估激光针刺疗法对接受化疗的儿童和青少年缓解恶心和呕吐的疗效。这是一项实验性、随机、单盲研究。该研究在位于巴西里约热内卢市的国家癌症研究所(INCA)进行,该机构是癌症控制和治疗方面的参考机构。该研究项目已获得INCA研究与伦理委员会批准,注册号为164/14,CAAE编号为3374551.0.3001.5274。选取了6至17岁正在接受具有高中度致吐毒性药物化疗的儿童和青少年。参与者被分为A组和B组。A组接受主动针刺治疗,B组接受安慰剂针刺治疗。数据分析表明,与安慰剂组相比,干预组的恶心症状得到了显著缓解。化疗第二天和第三天的呕吐发作次数也有所减少。在第1天、第4天和第5天,干预组与安慰剂组的呕吐发作次数没有显著差异。该研究得出结论,激光针刺疗法在化疗5天内缓解恶心以及减少化疗后第2天和第3天的呕吐发作次数方面是有效的。