Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Elife. 2019 Feb 25;8:e42786. doi: 10.7554/eLife.42786.
Animals consolidate some, but not all, learning experiences into long-term memory. Across the animal kingdom, sleep has been found to have a beneficial effect on the consolidation of recently formed memories into long-term storage. However, the underlying mechanisms of sleep dependent memory consolidation are poorly understood. Here, we show that consolidation of courtship long-term memory in is mediated by reactivation during sleep of dopaminergic neurons that were earlier involved in memory acquisition. We identify specific fan-shaped body neurons that induce sleep after the learning experience and activate dopaminergic neurons for memory consolidation. Thus, we provide a direct link between sleep, neuronal reactivation of dopaminergic neurons, and memory consolidation.
动物将部分但不是全部学习经验巩固为长期记忆。在整个动物界，已经发现睡眠对将新形成的记忆巩固到长期储存中具有有益的影响。然而，睡眠依赖性记忆巩固的潜在机制还知之甚少。在这里，我们表明，在 中求爱长期记忆的巩固是由睡眠期间多巴胺能神经元的再激活介导的，这些神经元在记忆获取过程中早些时候参与其中。我们确定了特定的扇形体神经元，它们在学习经验后诱导睡眠并激活多巴胺能神经元以进行记忆巩固。因此，我们在睡眠、多巴胺能神经元的神经元再激活和记忆巩固之间建立了直接联系。
