Zhao Xiaoliang, Lenek Daniela, Dag Ugur, Dickson Barry J, Keleman Krystyna
Janelia Research Campus, Ashburn, United States.
Research Institute of Molecular Pathology, Vienna, Austria.
Elife. 2018 Jan 11;7:e31425. doi: 10.7554/eLife.31425.
Recurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in relies on the recurrent circuit between mushroom body gamma (MBγ), M6 output, and aSP13 dopaminergic neurons. We demonstrate persistent neuronal activity of aSP13 neurons and show that it transiently potentiates synaptic transmission from MBγ>M6 neurons. M6 neurons in turn provide input to aSP13 neurons, prolonging potentiation of MB>M6 synapses over time periods that match short-term memory. These data support a model in which persistent aSP13 activity within a recurrent circuit lays the foundation for a short-term memory.
反复连接被认为是编码记忆的神经回路的一个共同特征，但记忆是如何在这样的回路中形成的，目前尚未完全了解。在这里，我们提供证据表明，[具体生物名称]中的求偶记忆依赖于蘑菇体γ（MBγ）、M6输出神经元和aSP13多巴胺能神经元之间的反复回路。我们证明了aSP13神经元的持续神经活动，并表明它短暂增强了从MBγ到M6神经元的突触传递。M6神经元反过来为aSP13神经元提供输入，随着时间的推移延长了MB到M6突触的增强，这与短期记忆相匹配。这些数据支持了一个模型，即反复回路中aSP13的持续活动为短期记忆奠定了基础。
