Ghazizadeh Yalda, Salehi Shadkami Hossein, Madani Fatemeh, Niknam Sedigheh, Adabi Mahdi
Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nanomedicine Student Association (NMA), Student's Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Nanomedicine (Lond). 2025 May;20(9):1029-1041. doi: 10.1080/17435889.2025.2486930. Epub 2025 Apr 5.
Nanotechnology has revolutionized cancer treatment by providing innovative solutions through nanocancer therapies, nanovaccines, and nanoparticles. This review focuses on the application of these technologies in colorectal cancer (CRC), highlighting their progression from preclinical studies to clinical trials. Nanoparticles, including liposomes, silica, gold, and lipid nanoparticles, possess unique properties that enhance drug delivery, improve therapeutic efficacy, and minimize systemic toxicity. Additionally, nanovaccines are being developed to elicit robust immune responses against CRC cells. This paper offers a comprehensive overview of the current state of nanotechnology-based treatments for CRC, emphasizing key preclinical studies and clinical trials that demonstrate their potential. Furthermore, the review discusses the challenges faced in this field. It outlines future directions for research, underscoring the need for ongoing efforts to translate these promising technologies into practical clinical applications.
纳米技术通过纳米癌症疗法、纳米疫苗和纳米颗粒提供创新解决方案，彻底改变了癌症治疗方式。本综述重点关注这些技术在结直肠癌（CRC）中的应用，突出其从临床前研究到临床试验的进展。纳米颗粒，包括脂质体、二氧化硅、金和脂质纳米颗粒，具有独特的性质，可增强药物递送、提高治疗效果并将全身毒性降至最低。此外，正在研发纳米疫苗以引发针对CRC细胞的强大免疫反应。本文全面概述了基于纳米技术的CRC治疗的现状，强调了证明其潜力的关键临床前研究和临床试验。此外，该综述讨论了该领域面临的挑战。它概述了未来的研究方向，强调了持续努力将这些有前景的技术转化为实际临床应用的必要性。
