培养的人脂肪间充质干细胞的单细胞 RNA-seq。
Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells.
机构信息
State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Center of Laboratory Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Division of Plastic Surgery, Peking Union Medical College Hospital, Beijing 100730, China.
出版信息
Sci Data. 2019 Feb 26;6:190031. doi: 10.1038/sdata.2019.31.
Adipose-derived mesenchymal stem cells (ADSCs) show considerable promise for clinical applications in regenerative medicine. We performed a large-scale single-cell transcriptomic sequencing of 24,358 cultured human ADSCs from three donors. We provide a high-quality dataset, which would be a valuable resource for dissecting the intrapopulation heterogeneity of cultured ADSCs as well as interrogating lineage priming patterns for any interested lineages at single-cell resolution.
脂肪来源间充质干细胞（ADSCs）在再生医学的临床应用中具有广阔的应用前景。我们对来自三个供体的 24358 个人类 ADSC 进行了大规模的单细胞转录组测序。我们提供了一个高质量的数据集，这将是一个有价值的资源，可用于剖析培养的 ADSC 种群内的异质性，以及以单细胞分辨率检测任何感兴趣谱系的谱系启动模式。
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