Hinton Pamela S, Nigh Peggy, Thyfault John
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, United States.
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, United States.
Bone. 2017 Mar;96:85-90. doi: 10.1016/j.bone.2016.10.011. Epub 2016 Oct 12.
We previously reported that 12months of resistance training (RT, 2×/wk, N=19) or jump training (JUMP, 3×/wk, N=19) increased whole body and lumbar spine BMD and increased serum bone formation markers relative to resorption in physically active (≥4h/wk) men (mean age: 44±2y; median: 44y) with osteopenia of the hip or spine. The purpose of this secondary analysis was to examine the effects of the RT or JUMP intervention on potential endocrine mediators of the exercise effects on bone, specifically IGF-I, PTH and sclerostin.
Fasting blood samples were collected after a 24-h period of no exercise at baseline and after 12months of RT or JUMP. IGF-I, PTH and sclerostin were measured in serum by ELISA. The effects of RT or JUMP on IGF-I, PTH and sclerostin were evaluated using 2×2 repeated measures ANOVA (time, group). This study was conducted in accordance with the Declaration of Helsinki and was approved by the University of Missouri IRB.
Sclerostin concentrations in serum significantly decreased and IGF-I significantly increased after 12months of RT or JUMP; while PTH remained unchanged.
The beneficial effects of long-term, progressive-intensity RT or JUMP on BMD in moderately active men with low bone mass are associated with decreased sclerostin and increased IGF-I.
我们之前报道过，对于髋部或脊柱骨质减少的体力活动活跃（每周≥4小时）男性（平均年龄：44±2岁；中位数：44岁），进行12个月的抗阻训练（RT，每周2次，N = 19）或跳跃训练（JUMP，每周3次，N = 19）可增加全身和腰椎骨密度，并使血清骨形成标志物相对于骨吸收增加。这项二次分析的目的是研究RT或JUMP干预对运动影响骨骼的潜在内分泌介质的作用，具体为胰岛素样生长因子-I（IGF-I）、甲状旁腺激素（PTH）和骨硬化蛋白。
在基线时经过24小时不运动期后以及RT或JUMP干预12个月后采集空腹血样。通过酶联免疫吸附测定法（ELISA）检测血清中的IGF-I、PTH和骨硬化蛋白。使用2×2重复测量方差分析（时间、组）评估RT或JUMP对IGF-I、PTH和骨硬化蛋白的影响。本研究按照《赫尔辛基宣言》进行，并获得密苏里大学机构审查委员会的批准。
RT或JUMP干预12个月后，血清中骨硬化蛋白浓度显著降低，IGF-I显著升高；而PTH保持不变。
长期、渐进强度的RT或JUMP对骨量低的中度活跃男性骨密度的有益影响与骨硬化蛋白降低和IGF-I升高有关。
