a Intensive Care Unit, Department of Critical Care Medicine, Beijing Friendship Hospital , Capital Medical University , Beijing , China.
b Department of Paediatrics, Zhengzhou Central Hospital , Zhengzhou University , Zhengzhou , China.
Int J Food Sci Nutr. 2019 Sep;70(6):668-674. doi: 10.1080/09637486.2019.1570490. Epub 2019 Feb 27.
Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet can lower blood pressure, but its role in preventing coronary artery disease (CAD) remains in debate. Thus, we performed a meta-analysis of prospective cohort studies to address this issue. We carried out a systematical search in databases of PubMed and Embase to screen out eligible publications. Relative risks (RRs) of CAD in the included studies were summarised using random-effect meta-analysis. Dose-response association between DASH diet score and CAD risk was also evaluated. Seven prospective studies were finally included, with a total of 377,725 participants and 15,074 CAD cases. Compared to lower adherence, higher adherence to the DASH diet was associated a decreased risk of CAD (RR 0.82, 95% confidence interval [CI]: 0.78-0.87). Subgroup and sensitivity analyses supported the preventive effects of DASH diet against CAD, and there was no indication of publication bias. For a curvilinear dose-response pattern, the RRs (95% CIs) of CAD for the 4 knots (5th, 35th, 65th and 95th percentiles) of DASH diet score were 0.93 (0.89-0.98), 0.87 (0.80-0.95), 0.81 (0.72-0.90) and 0.74 (0.68-0.82), respectively. For a linear dose-response manner, each 4-point increase in the DASH diet score could reduce the risk of CAD by 5% (RR 0.95, 95% CI: 0.94-0.97). The results of our study indicate that higher adherence to the DASH diet confers a reduced risk of developing CAD.
遵循膳食方法防治高血压（DASH）饮食可以降低血压，但它在预防冠心病（CAD）方面的作用仍存在争议。因此，我们进行了荟萃分析，以解决这个问题。我们在 PubMed 和 Embase 数据库中进行了系统搜索，以筛选出合格的出版物。使用随机效应荟萃分析总结了纳入研究中 CAD 的相对风险（RR）。还评估了 DASH 饮食评分与 CAD 风险之间的剂量-反应关系。最终纳入了 7 项前瞻性研究，共有 377725 名参与者和 15074 例 CAD 病例。与较低的依从性相比，较高的 DASH 饮食依从性与 CAD 风险降低相关（RR 0.82，95%置信区间 [CI]：0.78-0.87）。亚组和敏感性分析支持 DASH 饮食对 CAD 的预防作用，且不存在发表偏倚的迹象。对于曲线剂量-反应模式，DASH 饮食评分的 4 个结（第 5、35、65 和 95 百分位数）的 CAD 的 RR（95% CI）分别为 0.93（0.89-0.98）、0.87（0.80-0.95）、0.81（0.72-0.90）和 0.74（0.68-0.82）。对于线性剂量-反应方式，DASH 饮食评分每增加 4 分，CAD 的风险就降低 5%（RR 0.95，95% CI：0.94-0.97）。我们的研究结果表明，较高的 DASH 饮食依从性可降低发生 CAD 的风险。
