Iwasaki Tomohiro, Nakatsuka Ryo, Murase Kenya, Takata Hiroshige, Nakamura Hideya, Watano Satoru
Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, Japan.
Int J Mol Sci. 2013 Apr 29;14(5):9365-78. doi: 10.3390/ijms14059365.
This paper presents a simple method for the rapid synthesis of magnetite/hydroxyapatite composite particles. In this method, superparamagnetic magnetite nanoparticles are first synthesized by coprecipitation using ferrous chloride and ferric chloride. Immediately following the synthesis, carbonate-substituted (B-type) hydroxyapatite particles are mechanochemically synthesized by wet milling dicalcium phosphate dihydrate and calcium carbonate in a dispersed suspension of magnetite nanoparticles, during which the magnetite nanoparticles are incorporated into the hydroxyapatite matrix. We observed that the resultant magnetite/hydroxyapatite composites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 30 mass%, a temperature increase greater than 20 K was achieved in less than 50 s. These results suggest that our composites exhibit good hyperthermia properties and are promising candidates for hyperthermia treatments.
本文介绍了一种快速合成磁铁矿/羟基磷灰石复合颗粒的简单方法。在该方法中，首先通过使用氯化亚铁和氯化铁的共沉淀法合成超顺磁性磁铁矿纳米颗粒。合成后紧接着，在磁铁矿纳米颗粒的分散悬浮液中通过湿磨二水合磷酸二钙和碳酸钙，机械化学合成碳酸根取代的（B型）羟基磷灰石颗粒，在此过程中磁铁矿纳米颗粒被掺入羟基磷灰石基质中。我们观察到，所得的磁铁矿/羟基磷灰石复合材料具有磁铁矿纳米颗粒的均匀分散，其特征是没有大的聚集体。当这种材料受到交变磁场作用时，产生的热量随着磁铁矿浓度的增加而增加。对于30质量%的磁铁矿浓度，在不到50秒的时间内温度升高超过20K。这些结果表明，我们的复合材料表现出良好的热疗性能，是热疗治疗的有前途的候选材料。
