Farzin Ali, Fathi Mohammadhossein, Emadi Rahmatollah
Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran.
Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran; Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 1):21-31. doi: 10.1016/j.msec.2016.08.060. Epub 2016 Aug 24.
Hyperthermia and local drug delivery have been proposed as potential therapeutic approaches for killing cancer cells. The development of bioactive materials such as Hardystonite (HT) with magnetic and drug delivery properties can potentially meet this target. This new class of magnetic bioceramic can replace the widely used magnetic iron oxide nanoparticles, whose long-term biocompatibility is not clear. Magnetic HT can be potentially employed to develop new ceramic scaffolds for bone surgery and anticancer therapies. With this in mind, a synthesis procedure was developed to prepare multifunctional bioactive scaffold for tissue engineering, hyperthermia and drug delivery applications. To this end, iron (Fe)-containing HT scaffolds were prepared. The effect of Fe on biological, magnetic and drug delivery properties of HT scaffolds were investigated. The results showed that obtained Fe-HT is bioactive and magnetic with no magnetite or maghemite as secondary phases. The Fe-HT scaffolds obtained also possessed high specific surface areas and demonstrated sustained drug delivery. These results potentially open new aspects for biomaterials aimed at regeneration of large-bone defects caused by malignant bone tumors through a combination of hyperthermia, local drug delivery and osteoconductivity.
热疗和局部药物递送已被提议作为杀死癌细胞的潜在治疗方法。开发具有磁性和药物递送特性的生物活性材料，如钙硅酸锌（HT），有可能实现这一目标。这类新型磁性生物陶瓷可以替代广泛使用的磁性氧化铁纳米颗粒，其长期生物相容性尚不清楚。磁性HT可潜在地用于开发用于骨手术和抗癌治疗的新型陶瓷支架。考虑到这一点，开发了一种合成程序，以制备用于组织工程、热疗和药物递送应用的多功能生物活性支架。为此，制备了含铁（Fe）的HT支架。研究了Fe对HT支架的生物学、磁性和药物递送特性的影响。结果表明，所获得的Fe-HT具有生物活性和磁性，没有磁铁矿或磁赤铁矿作为第二相。所获得的Fe-HT支架还具有高比表面积，并表现出持续的药物递送。这些结果可能为生物材料开辟新的方向，旨在通过热疗、局部药物递送和骨传导性的组合来修复由恶性骨肿瘤引起的大骨缺损。
