Institute of Science and Technology for Ceramics-National Research Council, Faenza (RA) 48018, Italy.
Acta Biomater. 2012 Feb;8(2):843-51. doi: 10.1016/j.actbio.2011.09.032. Epub 2011 Sep 29.
The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe2+/Fe3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe2+ and Fe3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.
为了满足模板/支架再生过程中辅助骨和血管重塑的日益增长的需求，提出了使用磁激活的方法。有鉴于此，开发了一种合成工艺来制备具有超顺磁特性的生物活性（Fe2+/Fe3+）掺杂羟基磷灰石（Fe-HA）。这种新型磁性羟基磷灰石可潜在地用于开发具有增强的骨外科再生性能的新型磁性陶瓷支架；此外，磁性 Fe-HA 可应用于癌症治疗，以替代广泛使用的磁性氧化铁纳米颗粒，最近发现其长期细胞毒性已达到有害水平。对所得 Fe-HA 粉末进行了广泛的物理化学、微观结构和磁性表征，结果表明，在控制合成条件下，在磷灰石成核过程中同时添加 Fe2+和 Fe3+离子会在最终产物中诱导固有磁化，从而最大限度地减少了作为次要相的磁铁矿的形成。这一结果为旨在骨再生的生物器件和基于热疗的抗癌疗法开辟了新的前景。
