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对 中 Zn(II)₂Cys₆ 锌簇编码基因家族的全基因组分析及其光诱导表达。

Genome-Wide Analysis of the Zn(II)₂Cys₆ Zinc Cluster-Encoding Gene Family in and Its Light-Induced Expression.

机构信息

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China.

College of Life Science, University of Chinese Academy of Sciences, Beijing 100190, China.

出版信息

Genes (Basel). 2019 Feb 26;10(3):179. doi: 10.3390/genes10030179.

DOI:10.3390/genes10030179
PMID:30813610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6471507/
Abstract

The Zn(II)₂Cys₆ zinc cluster gene family is a subclass of zinc-finger proteins, which are transcriptional regulators involved in a wide variety of biological processes in fungi. We performed genome-wide identification and characterization of Zn(II)₂Cys₆ zinc-cluster gene (C6 zinc gene) family in , and . Based on the structures of the C6 zinc domains, these proteins were observed to be evolutionarily conserved in ascomycete fungi. We focused on , a medicinal fungus, and identified 139 C6 zinc genes which could be divided into three groups. Among them, 49.6% belonged to the fungal specific transcriptional factors, and 16% had a DUF3468 domain. Homologous and phylogenetic analysis indicated that 29 C6 zinc genes were possibly involved in the metabolic process, while five C6 zinc genes were supposed to be involved in asexual or sexual development. Gene expression analysis revealed that 54 C6 zinc genes were differentially expressed under light, including two genes that possibly influenced the development, and seven genes that possibly influenced the metabolic processes. This indicated that light may affect the development and metabolic processes, at least partially, through the regulation of C6 zinc genes in . Our results provide comprehensive data for further analyzing the functions of the C6 zinc genes.

摘要

锌指蛋白是一类转录调控因子，广泛参与真菌的多种生物学过程，而 Zn(II)₂Cys₆ 锌簇基因家族则是锌指蛋白的一个亚科。我们在 、 和 中进行了全基因组鉴定和特征分析，发现这些担子菌真菌中的 C6 锌簇基因（C6 锌基因）家族在进化上是保守的。我们专注于药用真菌 ，鉴定了 139 个 C6 锌基因，它们可以分为三组。其中，49.6%属于真菌特异性转录因子，16%具有 DUF3468 结构域。同源和系统发育分析表明，29 个 C6 锌基因可能参与代谢过程，而 5 个 C6 锌基因可能参与无性或有性发育。基因表达分析显示，54 个 C6 锌基因在光照下差异表达，其中两个基因可能影响发育，七个基因可能影响代谢过程。这表明，光照可能至少部分通过 C6 锌基因的调控影响 的发育和代谢过程。我们的研究结果为进一步分析 C6 锌基因的功能提供了全面的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/a2081b6c1236/genes-10-00179-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/e6568b84c5ab/genes-10-00179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/dc5ebe598d76/genes-10-00179-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/edb89ac5f9bb/genes-10-00179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/1a0d6a03a6aa/genes-10-00179-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/e8eac077035d/genes-10-00179-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/1e4cde4b1ce3/genes-10-00179-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/a2081b6c1236/genes-10-00179-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/e6568b84c5ab/genes-10-00179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/dc5ebe598d76/genes-10-00179-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/edb89ac5f9bb/genes-10-00179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/1a0d6a03a6aa/genes-10-00179-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/e8eac077035d/genes-10-00179-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/1e4cde4b1ce3/genes-10-00179-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58cd/6471507/a2081b6c1236/genes-10-00179-g007.jpg

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