Oh Jisun, Jang Chan Ho, Kim Jong-Sang
1School of Food Science and Biotechnology (BK21 PLUS Program), Kyungpook National University, Daegu, 41566 Republic of Korea.
2Institute of Agricultural Science and Technology, Kyungpook National University, Daegu, 41566 Republic of Korea.
Food Sci Biotechnol. 2018 Oct 25;28(1):1-6. doi: 10.1007/s10068-018-0498-7. eCollection 2019 Feb.
The well-demonstrated bioefficacy of phytochemicals in spite of their paradoxically low bioavailability has long puzzled scientists. Glyceollins, a family of soy-derived phytoalexins, have been reported to exert a variety of biological effects in vitro and in vivo systems in spite of poor systemic bioavailability after oral administration, suggesting that secondary messengers generated in gastrointestinal tract would transfer signals to target organs and tissues to manifest any effect. This review focuses on the potential mechanisms of how the poorly bioavailable glyceollins could still exert in vivo biological effects.
尽管植物化学物质的生物利用度出奇地低，但其已得到充分证实的生物功效长期以来一直困扰着科学家。大豆抗毒素是一类源自大豆的植物抗毒素，据报道，尽管口服后全身生物利用度较差，但它们在体外和体内系统中都能发挥多种生物学效应，这表明胃肠道中产生的第二信使会将信号传递给靶器官和组织以发挥任何效应。本综述重点关注生物利用度低的大豆抗毒素仍能发挥体内生物学效应的潜在机制。
