Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S 1085, F-35000 Rennes, France.
Laboratoire Nutrinov, Technopole Atalante Champeaux, 8 rue Jules Maillard de la Gournerie, 35012 Rennes Cedex, France.
Nutrients. 2019 Jan 3;11(1):79. doi: 10.3390/nu11010079.
Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications.
生物活性植物化合物，通常被称为植物化学物质，可以影响各种受体和转录因子或信号通路的表达和功能，这些受体和转录因子或信号通路在细胞功能中起着至关重要的作用，并且与人类健康和疾病有关。因此，植物化学物质可能具有预防和治疗慢性疾病的巨大潜力。大豆中分离出的一组植物抗毒素——glyceollins，因其对人体功能和疾病（尤其是抗癌作用）的多种影响而引起了关注。在这篇综述中，我们介绍了 glyceollins 的作用，以及它们在人类健康方面的潜在有益作用。尽管越来越多的研究表明，这种新的植物化学物质家族可能参与关键的细胞途径，如雌激素受体、蛋白激酶和脂质激酶信号通路，但仍需要进一步的研究来更好地了解它们的分子机制及其在生物医学应用中的特定意义。
