乳腺癌诊断时的晚期临床分期与较差的健康相关生活质量相关：一项横断面研究。
Advanced Clinical Stage at Diagnosis of Breast Cancer Is Associated with Poorer Health-Related Quality of Life: A Cross-Sectional Study.
作者信息
de Mello Ramirez Medina Julia, de Araujo Trugilho Ingrid, Mendes Giovanna Nunes Belo, Silva Josiel Guedes, da Silva Paiva Maria Alexsandra, de Aguiar Suzana Sales, Thuler Luiz Claudio Santos, Bergmann Anke
机构信息
Department of Clinical Epidemiology, National Cancer Institute, Rio de Janeiro, Brazil.
CEUMA University, Maranhão, Brazil.
出版信息
Eur J Breast Health. 2018 Dec 19;15(1):26-31. doi: 10.5152/ejbh.2018.4297. eCollection 2019 Jan.
Abstract
OBJECTIVE
To describe the clinical stage in women diagnosed with breast cancer and the association between clinical stage and Health-related quality of life (HRQoL).
MATERIALS AND METHODS
This was a cross-sectional study involving women diagnosed with breast cancer. HRQoL was assessed with European Organization for Research and Treatment of Cancer 30-Item Quality of Life Questionnaire and the Quality of Life Questionnaire Breast Cancer 23. The principal exposure was clinical stage (<IIB versus ≥IIB). Simple linear regression was performed and variables with p<0.20 were selected for the multiple linear regression. The final model was composed of statistically significant variables (p<0.05).
RESULTS
In total, 302 women were included. The majority (58.9%) had been diagnosed with advanced stage cancer (≥IIB). Those at an advanced clinical stage had poorer role functioning (p=0.029), pain (p<0.001), and symptoms in the breast (p<0.001).
CONCLUSION
Advanced clinical stage at diagnosis was found to be associated with worse health-related quality of life in breast cancer patients.
摘要
目的
描述被诊断为乳腺癌的女性的临床分期，以及临床分期与健康相关生活质量（HRQoL）之间的关联。
材料与方法
这是一项涉及被诊断为乳腺癌的女性的横断面研究。使用欧洲癌症研究与治疗组织的30项生活质量问卷和乳腺癌23项生活质量问卷对HRQoL进行评估。主要暴露因素为临床分期（<IIB期与≥IIB期）。进行简单线性回归，并选择p<0.20的变量进行多重线性回归。最终模型由具有统计学意义的变量（p<0.05）组成。
结果
总共纳入了302名女性。大多数（58.9%）被诊断为晚期癌症（≥IIB期）。处于临床晚期的患者在角色功能（p=0.029）、疼痛（p<0.001）和乳房症状（p<0.001）方面较差。
结论
发现诊断时的临床晚期与乳腺癌患者较差的健康相关生活质量相关。
相似文献
1
Advanced Clinical Stage at Diagnosis of Breast Cancer Is Associated with Poorer Health-Related Quality of Life: A Cross-Sectional Study.乳腺癌诊断时的晚期临床分期与较差的健康相关生活质量相关：一项横断面研究。
Eur J Breast Health. 2018 Dec 19;15(1):26-31. doi: 10.5152/ejbh.2018.4297. eCollection 2019 Jan.
2
Health-related quality of life in early breast cancer.早期乳腺癌患者的健康相关生活质量
Dan Med Bull. 2010 Sep;57(9):B4184.
3
Real-world patient-reported outcomes of women receiving initial endocrine-based therapy for HR+/HER2- advanced breast cancer in five European countries.在五个欧洲国家中，接受初始基于内分泌的治疗的 HR+/HER2- 晚期乳腺癌女性的真实世界患者报告结局。
BMC Cancer. 2020 Sep 7;20(1):855. doi: 10.1186/s12885-020-07294-2.
4
Evaluation of health-related quality of life in patients with breast cancer.乳腺癌患者健康相关生活质量评估。
Medicina (Kaunas). 2010;46(5):351-9.
5
Characteristics associated with significantly worse quality of life in mycosis fungoides/Sézary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study.来自前瞻性皮肤淋巴瘤国际预后指数（PROCLIPI）研究的蕈样肉芽肿/赛塞里综合征中与生活质量显著较差相关的特征。
Br J Dermatol. 2020 Mar;182(3):770-779. doi: 10.1111/bjd.18089. Epub 2019 Jul 28.
6
Worse quality of life in young and recently diagnosed breast cancer survivors compared with female survivors of other cancers: A cross-sectional study.与其他癌症女性幸存者相比，年轻及近期确诊的乳腺癌幸存者的生活质量更差：一项横断面研究。
Int J Cancer. 2016 Dec 1;139(11):2415-25. doi: 10.1002/ijc.30370. Epub 2016 Aug 16.
7
Dietary pattern and health-related quality of life among breast cancer survivors.乳腺癌幸存者的饮食模式与健康相关生活质量
BMC Womens Health. 2018 May 10;18(1):65. doi: 10.1186/s12905-018-0555-7.
8
Relationship between anxiety disorders and domains of health related quality of life among Nigerians with breast cancer.尼日利亚乳腺癌患者焦虑症与健康相关生活质量各领域之间的关系。
Breast. 2017 Feb;31:150-156. doi: 10.1016/j.breast.2016.11.010. Epub 2016 Nov 17.
9
Factors affecting health-related quality of life in women with recurrent breast cancer in Korea.影响韩国复发性乳腺癌女性健康相关生活质量的因素。
Qual Life Res. 2007 May;16(4):559-69. doi: 10.1007/s11136-006-9144-6. Epub 2007 Feb 6.
10
Health-related quality of life and the predictive role of sense of coherence, spirituality and religious coping in a sample of Iranian women with breast cancer: a prospective study with comparative design.伊朗乳腺癌女性样本中与健康相关的生活质量以及连贯感、精神性和宗教应对的预测作用：一项具有比较设计的前瞻性研究
Health Qual Life Outcomes. 2015 Mar 28;13:40. doi: 10.1186/s12955-015-0229-1.
引用本文的文献
1
The impact of sleep on breast cancer-specific mortality: a Mendelian randomisation study.睡眠对乳腺癌特异性死亡率的影响：一项孟德尔随机化研究。
BMC Cancer. 2025 Feb 26;25(1):357. doi: 10.1186/s12885-025-13681-4.
2
Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and EORTC QLQ-BR45 Questionnaires in Romania.评估器官衰竭和转移对乳腺癌患者生活质量的影响：一项基于在罗马尼亚使用欧洲癌症研究与治疗组织QLQ-C30和QLQ-BR45问卷的前瞻性研究。
J Pers Med. 2024 Feb 16;14(2):214. doi: 10.3390/jpm14020214.
3
Quality of Life and Treatment-Related Side Effects in Patients With HR+/HER2- Advanced Breast Cancer: Findings From a Multicountry Survey.激素受体阳性/人表皮生长因子受体 2 阴性晚期乳腺癌患者的生活质量和治疗相关副作用：一项多国家调查的结果。
Oncologist. 2023 Oct 3;28(10):856-865. doi: 10.1093/oncolo/oyad207.
4
Frailty and its association with health-related quality of life among older cancer patients: an evidence-based study from China.衰弱及其与老年癌症患者健康相关生活质量的关系：来自中国的循证研究。
Health Qual Life Outcomes. 2022 Aug 19;20(1):124. doi: 10.1186/s12955-022-02032-7.
5
Correlation between work productivity loss and EORTC QLQ-C30 and -BR23 domains from the MONALEESA-7 trial of premenopausal women with HR+/HER2- advanced breast cancer.绝经前HR+/HER2-晚期乳腺癌患者MONALEESA-7试验中工作效率损失与欧洲癌症研究与治疗组织核心问卷（QLQ-C30）及乳腺癌特异性问卷（-BR23）各领域之间的相关性
Ther Adv Med Oncol. 2022 Feb 28;14:17588359221081203. doi: 10.1177/17588359221081203. eCollection 2022.
6
Machine learning-based random forest for predicting decreased quality of life in thyroid cancer patients after thyroidectomy.基于机器学习的随机森林预测甲状腺癌患者甲状腺切除术后生活质量下降。
Support Care Cancer. 2022 Mar;30(3):2507-2513. doi: 10.1007/s00520-021-06657-0. Epub 2021 Nov 16.
7
Ribociclib plus fulvestrant for advanced breast cancer: Health-related quality-of-life analyses from the MONALEESA-3 study.来曲唑联合氟维司群治疗晚期乳腺癌：MONALEESA-3 研究的健康相关生活质量分析。
Breast. 2020 Dec;54:148-154. doi: 10.1016/j.breast.2020.09.008. Epub 2020 Sep 23.
8
Health-related quality of life in premenopausal women with hormone-receptor-positive, HER2-negative advanced breast cancer treated with ribociclib plus endocrine therapy: results from a phase III randomized clinical trial (MONALEESA-7).瑞博西尼联合内分泌治疗的激素受体阳性、HER2阴性晚期绝经前乳腺癌患者的健康相关生活质量：一项III期随机临床试验（MONALEESA-7）的结果
Ther Adv Med Oncol. 2020 Jul 26;12:1758835920943065. doi: 10.1177/1758835920943065. eCollection 2020.
9
Monitoring TNM stage of female breast cancer and survival across the South Australian population, with national and international TNM benchmarking: A population-based cohort study.监测南澳大利亚人群中女性乳腺癌的 TNM 分期和生存情况，并与全国和国际 TNM 基准进行比较：一项基于人群的队列研究。
BMJ Open. 2020 Jun 28;10(6):e037069. doi: 10.1136/bmjopen-2020-037069.
10
Primary Tumor Surgery for Patients with De Novo Stage IV Breast Cancer can Decrease Local Symptoms and Improve Quality of Life.原发肿瘤切除术治疗初诊 IV 期乳腺癌患者可减轻局部症状并提高生活质量。
Ann Surg Oncol. 2020 Apr;27(4):1025-1033. doi: 10.1245/s10434-019-08092-2. Epub 2020 Jan 22.
本文引用的文献
1
Sexual dysfunction in Spanish women with breast cancer.西班牙乳腺癌女性的性功能障碍。
PLoS One. 2018 Aug 31;13(8):e0203151. doi: 10.1371/journal.pone.0203151. eCollection 2018.
2
When do patient reported quality of life indicators become prognostic in breast cancer?患者报告的生活质量指标在乳腺癌中何时具有预后价值？
Health Qual Life Outcomes. 2018 Jan 12;16(1):13. doi: 10.1186/s12955-017-0834-2.
3
Health-related quality of life in different states of breast cancer - comparing different instruments.乳腺癌不同阶段的健康相关生活质量 - 比较不同的工具。
Acta Oncol. 2018 May;57(5):622-628. doi: 10.1080/0284186X.2017.1400683. Epub 2017 Nov 15.
4
Factors that Explain the Cancer-Related Insomnia.解释癌症相关失眠的因素。
Breast J. 2017 Jul;23(4):387-394. doi: 10.1111/tbj.12759. Epub 2017 Jan 24.
5
Patient-reported outcomes in ductal carcinoma in situ: A systematic review.导管原位癌患者报告结局的系统评价。
Eur J Cancer. 2017 Jan;71:95-108. doi: 10.1016/j.ejca.2016.09.035. Epub 2016 Dec 15.
6
Quality of Life among Breast Cancer Patients In Malaysia.马来西亚乳腺癌患者的生活质量
Asian Pac J Cancer Prev. 2016;17(4):1677-84. doi: 10.7314/apjcp.2016.17.4.1677.
7
Assessment of Quality of Life of Women with Breast Cancer.乳腺癌女性生活质量评估
Glob J Health Sci. 2016 Sep 1;8(9):52792. doi: 10.5539/gjhs.v8n9p1.
8
Determinants of advanced stage presentation of breast cancer in 87,969 Brazilian women.87969名巴西女性乳腺癌晚期表现的决定因素
Maturitas. 2015 Dec;82(4):365-70. doi: 10.1016/j.maturitas.2015.07.021. Epub 2015 Aug 29.
9
Stage, treatment and outcomes for patients with breast cancer in British Columbia in 2002: a population-based cohort study.2002年不列颠哥伦比亚省乳腺癌患者的分期、治疗及转归：一项基于人群的队列研究
CMAJ Open. 2013 Nov 7;1(4):E134-41. doi: 10.9778/cmajo.20130017. eCollection 2013 Oct.
10
Validity, reliability and understanding of the EORTC-C30 and EORTC-BR23, quality of life questionnaires specific for breast cancer.欧洲癌症研究与治疗组织生活质量核心问卷（EORTC-C30）和欧洲癌症研究与治疗组织乳腺癌特异性问卷（EORTC-BR23）的效度、信度及理解度
Rev Bras Epidemiol. 2013 Jun;16(2):352-63. doi: 10.1590/S1415-790X2013000200011.
Zotero 插件