de Mello Ramirez Medina Julia, de Araujo Trugilho Ingrid, Mendes Giovanna Nunes Belo, Silva Josiel Guedes, da Silva Paiva Maria Alexsandra, de Aguiar Suzana Sales, Thuler Luiz Claudio Santos, Bergmann Anke
Department of Clinical Epidemiology, National Cancer Institute, Rio de Janeiro, Brazil.
CEUMA University, Maranhão, Brazil.
Eur J Breast Health. 2018 Dec 19;15(1):26-31. doi: 10.5152/ejbh.2018.4297. eCollection 2019 Jan.
To describe the clinical stage in women diagnosed with breast cancer and the association between clinical stage and Health-related quality of life (HRQoL).
This was a cross-sectional study involving women diagnosed with breast cancer. HRQoL was assessed with European Organization for Research and Treatment of Cancer 30-Item Quality of Life Questionnaire and the Quality of Life Questionnaire Breast Cancer 23. The principal exposure was clinical stage (<IIB versus ≥IIB). Simple linear regression was performed and variables with p<0.20 were selected for the multiple linear regression. The final model was composed of statistically significant variables (p<0.05).
In total, 302 women were included. The majority (58.9%) had been diagnosed with advanced stage cancer (≥IIB). Those at an advanced clinical stage had poorer role functioning (p=0.029), pain (p<0.001), and symptoms in the breast (p<0.001).
Advanced clinical stage at diagnosis was found to be associated with worse health-related quality of life in breast cancer patients.
描述被诊断为乳腺癌的女性的临床分期，以及临床分期与健康相关生活质量（HRQoL）之间的关联。
这是一项涉及被诊断为乳腺癌的女性的横断面研究。使用欧洲癌症研究与治疗组织的30项生活质量问卷和乳腺癌23项生活质量问卷对HRQoL进行评估。主要暴露因素为临床分期（<IIB期与≥IIB期）。进行简单线性回归，并选择p<0.20的变量进行多重线性回归。最终模型由具有统计学意义的变量（p<0.05）组成。
总共纳入了302名女性。大多数（58.9%）被诊断为晚期癌症（≥IIB期）。处于临床晚期的患者在角色功能（p=0.029）、疼痛（p<0.001）和乳房症状（p<0.001）方面较差。
发现诊断时的临床晚期与乳腺癌患者较差的健康相关生活质量相关。
