Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.
Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Int J Oncol. 2019 May;54(5):1534-1544. doi: 10.3892/ijo.2019.4727. Epub 2019 Feb 27.
Cell division cycle 20 (CDC20) is a regulatory molecule and serves critical roles at multiple points of the cell cycle. Recent evidence indicates that CDC20 may serve an oncogenic role in a number of human cancer types. However, the role of CDC20 in primary cutaneous squamous cell carcinoma (cSCC) has not been studied, to the best of our knowledge. The aim of the present study was to investigate whether and how CDC20 is involved in the tumorigenesis of cSCC. The results revealed that CDC20 expression was significantly increased in cSCC tissues and cell lines, and its expression was associated with pathological differentiation. Downregulation of CDC20 inhibited cell proliferation, induced cell cycle arrest, promoted apoptosis and reduced migratory ability through inhibition of the Wnt/β‑catenin signaling pathway. Furthermore, all‑trans‑retinoic acid treatment significantly downregulated CDC20 expression in cSCC. The present results revealed that CDC20 may serve a crucial role in human cSCC, and suggested that CDC20 may be a novel biomarker for the prevention, diagnosis and treatment of cSCC.
细胞分裂周期蛋白 20（CDC20）是一种调节分子，在细胞周期的多个关键点发挥关键作用。最近的证据表明，CDC20 可能在多种人类癌症类型中发挥致癌作用。然而，据我们所知，CDC20 在原发性皮肤鳞状细胞癌（cSCC）中的作用尚未得到研究。本研究旨在探讨 CDC20 是否以及如何参与 cSCC 的肿瘤发生。结果显示，CDC20 在 cSCC 组织和细胞系中的表达显著增加，其表达与病理分化相关。下调 CDC20 通过抑制 Wnt/β-catenin 信号通路抑制细胞增殖，诱导细胞周期停滞，促进细胞凋亡和降低迁移能力。此外，全反式维甲酸处理可显著下调 cSCC 中的 CDC20 表达。本研究结果表明，CDC20 可能在人类 cSCC 中发挥重要作用，并提示 CDC20 可能成为预防、诊断和治疗 cSCC 的新型生物标志物。
