Tucker P W, Marcu K B, Slightom J L, Blattner F R
Science. 1979 Dec 14;206(4424):1299-303. doi: 10.1126/science.117548.
The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.
已确定小鼠γ2b免疫球蛋白重链恒定区的完整编码序列以及3'非翻译区。该序列的编码部分长1008个核苷酸（氨基酸残基114至449），3'非编码区在聚腺苷酸之前包含102个核苷酸。在核苷酸序列中出现了一个在γ2b或其他γ亚类蛋白质序列中未观察到的额外羧基末端赖氨酸残基，可能在翻译后进行加工。一个17个核苷酸的序列在CH1结构域中两次、在CH2结构域中一次以略有不同的形式出现在相同的相对位置，但翻译相位不同。该序列可能是γ2b.γ2a重链变体中的交叉位点，表明可能存在某种重组活性。
