LPCNO, Université de Toulouse, CNRS, INSA, UPS , 135 Avenue de Rangueil , 31077 Toulouse , France.
Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
ACS Nano. 2019 Mar 26;13(3):2870-2878. doi: 10.1021/acsnano.8b05671. Epub 2019 Mar 7.
Magnetic nanoparticles are important tools for biomedicine, where they serve as versatile multifunctional instruments for a wide range of applications. Among these applications, magnetic hyperthermia is of special interest for the destruction of tumors and triggering of drug delivery. However, many applications of magnetic nanoparticles require high-quality magnetic nanoparticles displaying high specific absorption rates (SARs), which remains a challenge today. We report here the functionalization and stabilization in aqueous media of highly magnetic 15 nm iron carbide nanoparticles featuring excellent heating power through magnetic induction. The challenge of achieving water solubility and colloidal stability was addressed by designing and using specific dopamine-based ligands. The resulting nanoparticles were completely stable for several months in water, phosphate, phosphate-buffered saline, and serum-containing media. Iron carbide nanoparticles displayed high SARs in water and viscous media (water/glycerol mixtures), even after extended exposition to water and oxygen (SAR up to 1000 W·g in water at 100 kHz, 47 mT). The cytotoxicity and cellular uptake of iron carbide nanoparticles could be easily tuned and were highly dependent on the chemical structure of the ligands used.
磁性纳米粒子是生物医药领域的重要工具，它们作为多功能的仪器，适用于广泛的应用。在这些应用中，磁热疗对于肿瘤的破坏和药物输送的触发特别有吸引力。然而，许多磁性纳米粒子的应用需要高质量的具有高比吸收率 (SAR) 的磁性纳米粒子，这在今天仍然是一个挑战。我们在这里报告了在水介质中对具有优异感应加热能力的高磁性 15nm 碳化铁纳米粒子进行功能化和稳定化。通过设计和使用特定的多巴胺基配体，解决了实现水溶性和胶体稳定性的挑战。所得纳米粒子在水中、磷酸盐、磷酸盐缓冲盐和含血清的介质中能稳定数月。碳化铁纳米粒子在水中和粘性介质（水/甘油混合物）中显示出高的 SAR，即使在长时间暴露于水和氧气后（在 100kHz、47mT 时，水中的 SAR 高达 1000W·g）。碳化铁纳米粒子的细胞毒性和细胞摄取可以很容易地进行调节，并且高度依赖于所用配体的化学结构。
