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本文引用的文献

1
Octapod iron oxide nanoparticles as high-performance T₂ contrast agents for magnetic resonance imaging.八足氧化铁纳米颗粒作为高性能 T₂ 磁共振成像对比剂。
Nat Commun. 2013;4:2266. doi: 10.1038/ncomms3266.
2
Fe5C2 nanoparticles: a facile bromide-induced synthesis and as an active phase for Fischer-Tropsch synthesis.Fe5C2 纳米颗粒：一种简便的溴化物诱导合成方法及其在费托合成中的活性相。
J Am Chem Soc. 2012 Sep 26;134(38):15814-21. doi: 10.1021/ja305048p. Epub 2012 Sep 12.
3
Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticles.利用工程化磁性纳米颗粒提高磁共振成像对比度和检测方法。
Theranostics. 2012;2(1):86-102. doi: 10.7150/thno.4006. Epub 2012 Jan 10.
4
Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy.多功能纳米颗粒在癌症成像与治疗中的靶向策略
Theranostics. 2012;2(1):3-44. doi: 10.7150/thno.3463. Epub 2012 Jan 1.
5
Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data.钴纳米粒子和离子的预测毒理学：使用数据知识发现方法对不同细胞模型的体外比较研究。
Toxicol Sci. 2011 Aug;122(2):489-501. doi: 10.1093/toxsci/kfr124. Epub 2011 May 20.
6
Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy.表面工程磁性纳米颗粒平台用于癌症成像和治疗。
Acc Chem Res. 2011 Oct 18;44(10):883-92. doi: 10.1021/ar200044b. Epub 2011 May 6.
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Multimodality Imaging of Integrin α(v)β(3) Expression.整合素 α(v)β(3)表达的多模态成像。
Theranostics. 2011 Feb 10;1:135-48. doi: 10.7150/thno/v01p0135.
8
Fine tuning of the relaxometry of γ-Fe2O3@SiO2 nanoparticles by tweaking the silica coating thickness.通过调整二氧化硅涂层厚度来优化 γ-Fe2O3@SiO2 纳米颗粒的弛豫率。
ACS Nano. 2010 Sep 28;4(9):5339-49. doi: 10.1021/nn101129r.
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Nanoparticle-based theranostic agents.基于纳米粒子的治疗诊断一体化试剂。
Adv Drug Deliv Rev. 2010 Aug 30;62(11):1064-79. doi: 10.1016/j.addr.2010.07.009. Epub 2010 Aug 4.
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Iron carbide: an ancient advanced material.碳化铁：一种古老的先进材料。
Small. 2010 Sep 6;6(17):1859-62. doi: 10.1002/smll.201000437.

具有高磁共振成像对比增强效果的Fe5C2纳米颗粒用于肿瘤成像。

Fe5C2 nanoparticles with high MRI contrast enhancement for tumor imaging.

作者信息

Tang Wei, Zhen Zipeng, Yang Ce, Wang Luning, Cowger Taku, Chen Hongmin, Todd Trever, Hekmatyar Khan, Zhao Qun, Hou Yanglong, Xie Jin

机构信息

Department of Chemistry and Bio-Imaging, Research Center (BIRC), University of Georgia, Athens, GA, 30602, USA.

出版信息

Small. 2014 Apr 9;10(7):1245-9. doi: 10.1002/smll.201303263. Epub 2013 Dec 18.

DOI:10.1002/smll.201303263
PMID:24352976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6398947/
Abstract

An ancient material for magnetic resonance (MR) imaging: For the first time, Fe5C2 is prepared as colloidal stable nanoparticles with good aqueous stability. The nanoparticles boast strong magnetization, excellent chemical inertness, low toxicity, and one of the highest r2 relaxivities reported to date. These nanoparticles hold great potential in MR imaging as well as in other biomedical areas.

摘要

一种用于磁共振成像的古老材料

首次将Fe5C2制备成具有良好水稳定性的胶体稳定纳米颗粒。这些纳米颗粒具有强磁化性、优异的化学惰性、低毒性以及迄今为止报道的最高r2弛豫率之一。这些纳米颗粒在磁共振成像以及其他生物医学领域具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/35279595df5c/nihms-1001407-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/8b08081ff40e/nihms-1001407-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/22deba510abf/nihms-1001407-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/35279595df5c/nihms-1001407-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/8b08081ff40e/nihms-1001407-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/fc50aa8a3147/nihms-1001407-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/22deba510abf/nihms-1001407-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d4/6398947/35279595df5c/nihms-1001407-f0004.jpg