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褐藻提取物的成骨潜力。

The Osteogenic Potential of Brown Seaweed Extracts.

机构信息

School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, UK.

School of Medicine, Dentistry & Biomedical Science, Queen's University Belfast 97 Lisburn Road, Belfast BT9 7BL, UK.

出版信息

Mar Drugs. 2019 Feb 28;17(3):141. doi: 10.3390/md17030141.

DOI:10.3390/md17030141
PMID:30823356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6470556/
Abstract

Marine drugs hold significantly more promise than their terrestrial counterparts, which could help to solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, and . studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals, which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested, failing to support previously reported positive effects.

摘要

海洋药物比陆地药物具有更大的潜力，可以帮助解决骨质疏松症和其他骨骼相关疾病的治疗短缺问题。岩藻黄质是褐藻中发现的主要类胡萝卜素，具有许多被认为对健康有益的特性，包括潜在的骨骼治疗特性。本研究评估了纯岩藻黄质和粗提取物对成骨的影响，这些提取物含有从两种潮间带褐藻中分离出的岩藻黄质和酚类成分（也被认为具有成骨潜力）。研究使用人胎成骨细胞系（hFOBs）和原代人骨髓基质细胞（hBMSCs）进行。结果发现，高浓度的纯岩藻黄质对 hFOBs 的细胞增殖有抑制作用，而含有多酚和岩藻黄质的粗提取物则具有清除自由基的能力，从而掩盖了这种作用。在两种测试的细胞类型中，没有一种提取物表现出强烈的促骨生成作用，未能支持之前报道的积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/605703464105/marinedrugs-17-00141-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/45f9942aaa57/marinedrugs-17-00141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/14d78d88a21d/marinedrugs-17-00141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/28ba6ad55bd8/marinedrugs-17-00141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/538986aa5c5f/marinedrugs-17-00141-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/b261aa8c6ffb/marinedrugs-17-00141-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/605703464105/marinedrugs-17-00141-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/45f9942aaa57/marinedrugs-17-00141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/14d78d88a21d/marinedrugs-17-00141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/28ba6ad55bd8/marinedrugs-17-00141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/538986aa5c5f/marinedrugs-17-00141-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/b261aa8c6ffb/marinedrugs-17-00141-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e27b/6470556/605703464105/marinedrugs-17-00141-g006.jpg

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