Karpiński Tomasz M, Adamczak Artur
Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.
Department of Botany, Breeding and Agricultural Technology of Medicinal Plants, Institute of Natural Fibres and Medicinal Plants, Kolejowa 2, 62-064 Plewiska, Poland.
Antioxidants (Basel). 2019 Jul 24;8(8):239. doi: 10.3390/antiox8080239.
Fucoxanthin is a carotenoid produced by brown algae and diatoms. This compound has several biological properties such as antioxidant, anti-obesity, anti-diabetic, anticancer, and antimicrobial activities. Unfortunately, until now the latter effect has been poorly confirmed. The aim of this study was an evaluation of fucoxanthin activity against 20 bacterial species. Antimicrobial effect of fucoxanthin was determined by using the agar disc-diffusion and micro-dilution methods. The studied carotenoid acted against 13 bacteria growing in aerobic conditions. It was observed to have a significantly stronger impact on Gram-positive than Gram-negative bacteria. Mean zones of growth inhibition (ZOIs) for Gram-positive bacteria ranged between 9.0 and 12.2 mm, while for Gram-negative were from 7.2 to 10.2 mm. According to the agar disc-diffusion method, the highest activity of fucoxanthin was exhibited against (mean ZOI 12.2 mm), (mean ZOI 11.2 mm), and (mean ZOI 11.0 mm), and in the microdilution test towards with the minimal inhibitory concentration (MIC) of 62.5 µg/mL. On the other hand, fucoxanthin was not active against strict anaerobic bacteria.
岩藻黄质是一种由褐藻和硅藻产生的类胡萝卜素。这种化合物具有多种生物学特性，如抗氧化、抗肥胖、抗糖尿病、抗癌和抗菌活性。遗憾的是，到目前为止，后者的作用尚未得到充分证实。本研究的目的是评估岩藻黄质对20种细菌的活性。采用琼脂平板扩散法和微量稀释法测定岩藻黄质的抗菌效果。所研究的类胡萝卜素对13种需氧生长的细菌有作用。观察到它对革兰氏阳性菌的影响明显强于革兰氏阴性菌。革兰氏阳性菌的平均生长抑制圈（ZOIs）在9.0至12.2毫米之间，而革兰氏阴性菌的平均生长抑制圈在7.2至10.2毫米之间。根据琼脂平板扩散法，岩藻黄质对（平均ZOI 12.2毫米）、（平均ZOI 11.2毫米）和（平均ZOI 11.0毫米）表现出最高活性，在微量稀释试验中对的最低抑菌浓度（MIC）为62.5微克/毫升。另一方面，岩藻黄质对严格厌氧菌没有活性。
