Department of Clinical Science and Education, Karolinska Institutet, and Sachs' Children and Youth Hospital, Södersjukhuset, 11883 Stockholm, Sweden.
Institute for Immunological Research, University of Cartagena, Cartagena 130015, Colombia.
Int J Mol Sci. 2019 Mar 1;20(5):1060. doi: 10.3390/ijms20051060.
Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including , , and . In this study, we measured H3 and H4 histone acetylation levels by chromatin immunoprecipitation in 173 term placentas collected in the prospective birth cohort, ALADDIN, in which information on lifestyle and diet is thoroughly recorded. In anthroposophic families, regular olive oil usage during pregnancy was associated with increased H3 acetylation at ( = 0.004), ( = 0.008), and ( = 0.007) promoters, which remained significant after adjustment by offspring gender. Furthermore, maternal fish consumption was associated with increased H4 acetylation at the gene in placentas of female offspring ( = 0.009). In conclusion, prenatal olive oil intake can affect placental histone acetylation in immune regulatory genes, confirming previously observed pro-acetylation effects of olive oil polyphenols. The association with fish consumption may implicate ω-3 polyunsaturated fatty acids present in fish oil. Altered histone acetylation in placentas from mothers who regularly include fish or olive oil in their diets could influence immune priming in the newborn.
母体饮食可修饰后代的表观遗传编程，这是现代社会免疫失调的一个潜在关键因素。我们之前发现，产前补充鱼油会影响新生儿 T 细胞中与适应性免疫相关基因的组蛋白乙酰化，这些基因包括 、 和 。在这项研究中，我们通过在前瞻性出生队列 ALADDIN 中收集的 173 个足月胎盘的染色质免疫沉淀，测量了 H3 和 H4 组蛋白乙酰化水平，该队列中详细记录了生活方式和饮食信息。在人智学家庭中，怀孕期间定期使用橄榄油与 （=0.004）、 （=0.008）和 （=0.007）启动子处 H3 乙酰化增加有关，在按后代性别调整后仍然显著。此外，母亲的鱼类摄入量与女性后代胎盘 基因处 H4 乙酰化增加有关（=0.009）。总之，产前橄榄油摄入可影响免疫调节基因中的胎盘组蛋白乙酰化，证实了先前观察到的橄榄油多酚的促乙酰化作用。与鱼类消费的关联可能涉及存在于鱼油中的 ω-3 多不饱和脂肪酸。经常在饮食中摄入鱼类或橄榄油的母亲的胎盘组蛋白乙酰化改变可能会影响新生儿的免疫启动。
