脯氨酸转运蛋白介导的脯氨酸转运在大肠杆菌渗透调节中也起作用。
proP-mediated proline transport also plays a role in Escherichia coli osmoregulation.
作者信息
Gowrishankar J
出版信息
J Bacteriol. 1986 Apr;166(1):331-3. doi: 10.1128/jb.166.1.331-333.1986.
Abstract
The growth of Escherichia coli strains in media having elevated osmolarity was promoted in the presence of low concentrations of the L-proline analog 5-hydroxy-L-pipecolic acid. The osmoprotective ability of this compound was correlated with the presence in these strains of a functional proP+ gene. The results suggest that the proP-mediated transport of L-proline (in addition to that by proU) is important in osmoregulation. proP::lac operon fusions were used to demonstrate that this gene shows limited induction of expression upon growth in media having elevated osmolarity and that it is transcribed clockwise on the chromosome.
摘要
在低浓度L-脯氨酸类似物5-羟基-L-哌可酸存在的情况下，大肠杆菌菌株在渗透压升高的培养基中的生长得到促进。该化合物的渗透保护能力与这些菌株中功能性proP⁺基因的存在相关。结果表明，proP介导的L-脯氨酸转运（除了proU介导的转运之外）在渗透调节中很重要。利用proP::lac操纵子融合来证明该基因在渗透压升高的培养基中生长时表达诱导有限，并且它在染色体上按顺时针方向转录。
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