Department of Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
Faculty of Psychology and Education, University of Tehran, Iran.
Explore (NY). 2019 Jul-Aug;15(4):308-315. doi: 10.1016/j.explore.2019.01.004. Epub 2019 Feb 4.
Increasing physical activity and promoting healthy behaviors may play a key role in reducing the adverse effects of antiretroviral therapy and HIV.
This study investigated the effects of an 8-week lifestyle modification program (LMP) on quality of life, anthropometric characteristics and CD4+T cell count of people living with HIV (PLWH).
Thirty PLWH taking ART were randomly assigned to a lifestyle modification program (LMP) (n = 15) or standard care control (CON) group (n = 15). All volunteers underwent body composition, CD4+T cell count measurement and quality of life assessments at the beginning and end of a two-month experimental period.
At follow-up, we observed a significant increase in CD4+T cell count (117.52 cells/mm; 95% CI, 36.59-198.45) and all subscales and total quality of life score (Short-Form 36 (SF-36) in the LMP group. While we did not observe a significant change in body composition for the LMP group, we did observe a significant increase in body fat (1.75%; 95% CI, 0.15, 2.33) and a reduction in lean body mass (-1.26; 95% CI, -1.26, -2.39) for the CON group.
A LMP can be safely used as an effective intervention for improving quality of life and immune competence of PLWH who lack time to participate in a structured exercise regimen.
IRCT 201604034076N18. Registered: 2016-05-05 .web address of TRIAL: en.search.irct.ir/trial/4262.
增加身体活动和促进健康行为可能在减轻抗逆转录病毒治疗和 HIV 的不良影响方面发挥关键作用。
本研究调查了 8 周生活方式改变方案（LMP）对接受抗逆转录病毒治疗的 HIV 感染者（PLWH）生活质量、人体测量特征和 CD4+T 细胞计数的影响。
30 名接受 ART 的 PLWH 被随机分配到生活方式改变方案（LMP）组（n=15）或标准护理对照组（CON）组（n=15）。所有志愿者在为期两个月的实验期开始和结束时进行身体成分、CD4+T 细胞计数测量和生活质量评估。
随访时，我们观察到 LMP 组 CD4+T 细胞计数（117.52 个/毫米；95%CI，36.59-198.45）和所有子量表和总生活质量评分（短期表格 36（SF-36）显著增加。虽然我们没有观察到 LMP 组的身体成分有显著变化，但我们确实观察到 CON 组的体脂增加（1.75%；95%CI，0.15，2.33）和瘦体重减少（-1.26%；95%CI，-1.26，-2.39）。
LMP 可作为一种安全有效的干预措施，用于改善缺乏时间参加结构化运动方案的 PLWH 的生活质量和免疫能力。
IRCT 201604034076N18. 注册时间：2016 年 5 月 5 日。试验网址：en.search.irct.ir/trial/4262。
