SetPoint Medical, Inc., Valencia, California 91355.
Cold Spring Harb Perspect Med. 2020 Jan 2;10(1):a034330. doi: 10.1101/cshperspect.a034330.
Treating diseases nonpharmacologically, using targeted neurostimulation instead of systemic drugs, is a hallmark of the burgeoning field of bioelectronic medicine. In this review, we provide a brief overview of the discovery and function of the prototypical neuroimmune reflex, the "inflammatory reflex." We discuss various biomarkers developed and used to translate early physiological discoveries into dosing parameters used in experimental settings, from the treatment of animal models of disease through a proof-of-concept clinical study in rheumatoid arthritis (RA). Finally, we relate how unique aspects of this form of therapy enabled the design of a next-generation implanted pulse generator using integrated electrodes, currently under evaluation in a U.S.-based clinical study for patients with drug refractory RA.
非药物治疗疾病，采用靶向神经刺激代替全身药物，是新兴的生物电子医学领域的标志。在这篇综述中，我们简要介绍了原型神经免疫反射——“炎症反射”的发现和功能。我们讨论了各种生物标志物的开发和应用，这些标志物将早期生理发现转化为实验设置中使用的剂量参数，从疾病动物模型的治疗到类风湿关节炎（RA）的概念验证临床研究。最后，我们将讨论这种治疗形式的独特方面如何能够设计出一种使用集成电极的新一代植入脉冲发生器，该发生器目前正在美国进行药物难治性 RA 患者的临床研究中进行评估。
