Crouse J R, Harpold G H, Kahl F R, Toole J F, McKinney W M
Stroke. 1986 Mar-Apr;17(2):270-5. doi: 10.1161/01.str.17.2.270.
We have developed a scoring system to quantify extent of extracranial carotid artery atherosclerosis using real-time ultrasound (B-mode). To evaluate repeatability of this scoring system we correlated repeat scores obtained within a short interval of one another (6 months) in 52 individuals. We compared repeatability of extent measurements with repeatability of a measure of severity (single most severe lesion). Correlations between first and second studies for severity were weak (r2 = 0.20) but significant (p less than 0.001). Extent scores correlated much better (r2 = 0.77, p less than 0.001). In another group of 22 patients we found that the extent of atherosclerosis decreased following endarterectomy. We used this method to determine changes in extent of carotid atherosclerosis with age in two sets of individuals. One consisted of a cohort of 22 patients who underwent repeat B-mode studies separated by 1 1/2-3 years. This cohort demonstrated an increase in carotid score with age (p less than 0.05). In a second group of volunteers undergoing cardiac catheterization and B-mode evaluation of the carotid system, carotid scores could be compared in individuals with age differences that averaged 15 years. Extent of carotid atherosclerosis was significantly greater in older individuals (p less than 0.01) and differences in extent with age were exaggerated in patients with coronary disease compared to coronary disease free controls.
我们开发了一种评分系统，用于使用实时超声（B 模式）量化颅外颈动脉粥样硬化的程度。为了评估该评分系统的可重复性，我们对 52 名个体在短时间间隔（6 个月）内获得的重复评分进行了相关性分析。我们将程度测量的可重复性与严重程度测量（单个最严重病变）的可重复性进行了比较。首次和第二次研究中严重程度的相关性较弱（r2 = 0.20），但具有显著性（p 小于 0.001）。程度评分的相关性要好得多（r2 = 0.77，p 小于 0.001）。在另一组 22 名患者中，我们发现动脉内膜切除术后动脉粥样硬化程度降低。我们使用这种方法来确定两组个体中颈动脉粥样硬化程度随年龄的变化。一组由 22 名患者组成，他们在 1.5 - 3 年的间隔后接受了重复的 B 模式研究。该队列显示颈动脉评分随年龄增加（p 小于 0.05）。在另一组接受心脏导管检查和颈动脉系统 B 模式评估的志愿者中，可以比较年龄差异平均为 15 岁的个体的颈动脉评分。老年个体的颈动脉粥样硬化程度明显更高（p 小于 0.01），与无冠心病的对照组相比，冠心病患者中程度随年龄的差异更为明显。
